摘要
目的对血红素加氧酶1(Heme oxygenase 1,HO-1)修饰MSCs的相关研究进展进行综述。方法广泛查阅HO-1修饰MSCs的相关研究文献报道,对HO-1修饰MSCs的意义、效应及其相关机制进行总结综述。结果 HO-1修饰MSCs具有重要的研究价值,能够有效增强MSCs移植入体内后在复杂内环境下的抗氧化应激、抗凋亡特性,同时有效增强了MSCs的免疫调节功能,在各种疾病模型及研究领域中提高了MSCs的抗损伤、修复及免疫调控效果。结论 HO-1修饰MSCs的基础研究取得显著进展,有望应用于临床试验,并为干细胞治疗提供一定的理论依据及参考价值。
Objective To review the literature reports on research progress of Heme oxygenase 1(HO-1 modified mesenchymal stem cells(MSCs). Methods The significance, effects, and related mechanism of HO-1 modification of MSCs were summarized by consulting the related literatures and reports of HO-1 modification of MSCs.Results HO-1 modification of MSCs has important research value. It can effectively enhance the anti-oxidative stress and anti-apoptotic properties of MSCs in complex internal environment after transplantation into vivo. It can also effectively enhance the immune regulation function of MSCs. It can improve the anti-injury, repair, and immune regulation effect of MSCs in various disease models and research fields. Conclusion The basic research of HO-1 modified MSCs has made remarkable progress, which is expected to be applied in clinical trials and provide theoretical basis and reference value for stem cell therapy.
作者
孙东
宋红丽
沈中阳
SUN Dong;SONG Hongli;SHEN Zhongyang(The First Central Clinical College,Tianjin Medical University,Tianjin,300192,P.R.China;Department of Organ Transplantation,Tianjin First Central Hospital,Tianjin Key Laboratory of Organ Transplantation,Key Laboratory of Transplantation Medicine,Chinese Academy of Medical Sciences,Tianjin,300192,P.R.China)
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2019年第7期901-906,共6页
Chinese Journal of Reparative and Reconstructive Surgery
基金
国家自然科学基金资助项目(81670574)~~
关键词
MSCS
血红素加氧酶1
抗凋亡
免疫调控
研究进展
Mesenchymal stem cells
Heme oxygenase 1
anti-apoptosis
immunoregulation
research progress
