焦虑抑郁共病障碍的研究进展

Progress in the Comorbidity of Depression and Anxiety

传统观点将焦虑障碍和抑郁障碍视为两个独立的疾病单元,然而,在临床实践和流行病学调查中,焦虑抑郁共病的发病率高,且预后差。该文介绍了共病障碍的基本概念,共病特点,治疗措施以及相关的动物模型,着重讨论新的动物模型的建立和新型抗焦虑和抗抑郁双重治疗药物的开发对焦虑和抑郁共病障碍诊断、治疗和预防的积极意义。

It is traditionally thought that anxiety disorder and depressive disorder are categorically defined as two individual psychiatric disorders. As clinical practice and epidemiological studies show,however,the comorbidity of depression and anxiety is prevalent and of poorer outcomes than either disorder alone. In this review,the concepts,clinical features, therapeutic managements,and animal models related to the comorbidity of depression and anxiety are well addressed. In addition,establishing the novel animal models and developing the new agents of both anti-depression and-anxiety are discussed to improve its diagnosis,treatment,and medical prevention.