天然化合物治疗缺血性脑卒中抗氧化作用机制的研究进展

The Research Progress of the Antioxidant Effect of Natural Compounds in the Treatment of Ischemic Stroke

脑卒中是一种发病率、致死率、致残率极高的常见疾病,对人类生命、社会经济及医疗资源造成了巨大的威胁。缺血性脑卒中患者占脑卒中患者80%,缺血后再灌注引发更强烈的神经损伤,包括兴奋性毒性、氧化应激、炎症反应等,其中氧化应激是损伤最关键的原因之一。我国的天然产物资源丰富,且传统医药学历史悠久、经验丰富,从天然资源中研究和开发高效、低毒、安全、价廉的天然产物具有独特优势,这对国内外提高缺血性脑卒中治疗水平具有重要的医学价值。该文综述了丁基苯酞、丹酚酸、原儿茶醛等天然化合物治疗缺血性脑卒中的作用机制与其抗氧化活性相关。

Stroke is a common disease with high incidence,mortality and disability, which poses a huge threat to human life,social economy,and medical resources. Ischemic stroke patients account for 80% of stroke patients,and reperfusion after ischemia induces more intense nerve damage,including excitotoxicity,oxidative stress,and inflammatory response. Among them,oxidative stress is one of the most critical causes of injury. China’s natural products are rich in resources,and traditional medicine has a long history and rich experience. It has unique advantages in researching and developing high-efficiency,low-toxic,safe and inexpensive natural products from natural resources,which has improve ischemic stroke at home and abroad. The level of treatment has important medical value.In this paper,natural compounds such as butylphthalide,salvianolic acid,and protocatechuic aldehyde are reviewed. The mechanism of action of these compounds in the treatment of ischemic stroke is related to its antioxidant activity.