巨细胞病毒感染对体外受精-胚胎移植妊娠结局的影响

Cytomegalovirus Infection and the Outcome of IVF-ET

目的:探讨巨细胞病毒(CMV)感染对不孕症患者行体外受精/胞浆内单精子注射(IVF/ICSI治疗妊娠结局的影响。方法:2005年8月-2018年1月间在本院进行辅助生殖治疗的59 536例患者,按是否感染CMV分为CMV IgG阳性组(94例)和CMV IgG阴性组(26 483例),分析CMV感染后对辅助生殖治疗患者妊娠结局的影响。结果:2组患者年龄、不孕时间、不育时间、体质量指数、基础卵泡刺激素(FSH)等比较差异均无统计学意义(P>0.05),但CMV IgG阳性组较CMV IgG阴性组IVF卵子数、IVF 2PN数、生化妊娠率和临床妊娠率均降低,差异有统计学意义(P<0.05)。结论:既往CMV感染后可降低患者行IVF-ET治疗的IVF卵子数、IVF2PN数、生化妊娠率和临床妊娠率。CMV IgG阳性对患者的IVF/ICSI结局有不良影响。

Objective:To investigate the effect of cytomegalovirus(CMV) infection on the pregnancy outcomes of IVF/ICSI treatment. Methods:The data of 59 536 patients who underwent ART treatment in our center between August 2005 and January 2018 were retrospectively analyzed. These patients were divided into two groups: the CMV IgG positive group(n=94) and the CMV IgG negative group(n=26 483). The pregnancy outcomes were compared accordingly. Results:There were no significantly differences in the age, infertile duration, body mass index, base level of FSH between the two groups(all P>0.05). The number of retrieved oocytes, the number of 2PN after IVF, the rate of biochemical pregnancy, and the rate of clinical pregnancy in the CMV IgG positive group were significantly lower than those in the CMV IgG negative group(all P<0.05). Conclusions:The number of retrieved oocytes, the number of 2PN after IVF, the rate of biochemical pregnancy, and the rate of clinical pregnancy could be lowered in those patients with the history of CMV infection. The CMV positive infection may affect the clinical outcomes of IVF/ICSI treatment.