全氟类化合物在人体与动物体内的生殖毒性

Reproductive Toxicity of Polyfluorinated Chemicals: A Mini Review

全氟类化合物(polyfluorinated chemicals,PFCs)是一类来自工业生产,存在于人们日常生活环境中内分泌干扰物(endocrine disruptors,EDCs)。研究表明,PFCs可以聚集在生物体内,并通过影响甾体激素合成、诱导生殖系统细胞凋亡、拮抗激素受体等机制,在生殖系统表现出毒性作用。在男性中,这类物质被证明与精子的质量与数量的下降及异常精子比率的上调有关,干扰男性性激素水平(如睾酮);而在女性中也发现血液或卵泡液中PFCs水平的升高,往往伴随着性激素及促性腺激素(如雌孕激素,卵泡刺激素等)水平的异常以及生育力的下降,这类物质在孕期的暴露甚至有影响至下一代的可能。此外,已有动物实验从分子层面对这类物质的毒性机制进行了证实,因此PFCs的生殖毒性值得关注。

Polyfluorinated chemicals(PFCs) are a series of endocrine disruptors(EDCs) generated from industrial production and existing in environment of daily life. PFCs can be accumulated in animal tissues, and perform reproductive toxicity through different mechanisms such as disrupting steroidogenesis, inducing apoptosis of reproductive cells and acting as antagonism of hormone receptors. In male, PFCs were found to be associated with the decreased sperm quality and concentration, and the increased rate of sperm deformation, and to disturb sexual hormones such as testosterone. In female, PFCs increased in blood or follicular fluid were related to the decreased fertility. Moreover, the exposure to PFCs during pregnancy may affect the health and fertility of offspring. The molecular mechanisms of this kind of chemicals have been studied in many animal experiments. In conclusion, we should pay attention to the reproductive toxicity of PFCs.