蛋白质组学分析在复发性流产患者不同临床标本中的应用

Application of Proteomics Analysis in Different Specimens of Recurrent Spontaneous Abortion

复发性流产(RSA)是一种临床常见但病因尚未完全阐明的疾病,需要在分子水平上进一步深入研究。随着蛋白质组学技术的广泛应用,许多体液和组织都可以用于RSA的病因探索。回顾近年来国内外学者对RSA患者卵泡液、胎盘绒毛、血液和子宫内膜等不同临床标本进行蛋白质组学研究的结果,通过比较和分析临床常用标本的特征,发现血浆和子宫内膜是更为适宜应用蛋白质组学技术分析RSA病因的体液和组织。本文有助于我们客观认识蛋白质组学技术在RSA病因机制研究和早期诊断中的应用价值。

Recurrent spontaneous abortion(RSA) is a common disease, but the etiology can’t be fully explained. It is need to explore more deeply at molecular level. With the wide use of a series of complex proteomics techniques, many body fluids and tissues have been used in the etiological study of RSA. In this paper,the proteomic studies of different body fluids and tissues including follicular fluid, placental villi, blood and endometrium of patients with RSA in recent years were reviewed. Through comparing the characteristics of common clinical specimens one by one, we believe that plasma and endometrium are more suitable for the proteomic study of RSA etiology. This review is helpful for us to understand objectively the application of proteomics in the etiological study and early diagnosis of RSA.