人RPE细胞通过隧道纳米管传递钙信号的研究进展

Research progress of calcium signaling by tunneling nanotubes in human RPE cells

Ca^2+信号传导在细胞生理过程中至关重要,Ca^2+是决定细胞命运的主要信号分子,包括细胞分化和细胞死亡。细胞间通讯也是依赖于Ca^2+信号的传导,近年来,报道了一种新型的动物细胞间通讯,它连接单个细胞并选择性的促进远距离细胞与细胞之间的通讯,这些高度敏感的纳米管状结构被称为隧道纳米管(tunneling nanotubes,TNT),人视网膜色素上皮细胞(retinal pigment epithelial,RPE)细胞株Arpe-19具有TNT来交换细胞间的分子信息,并且可以利用Ca^2+显像技术来显示细胞间钙信号通过TNT传递,人RPE细胞系通过隧道纳米管进行通讯,为RPE细胞之间的通讯提供了一种新的途径,因此,未来需要进一步研究细胞间通过隧道纳米管传递钙离子。

Ca^2+ signaling is essential in cellular physiology,and Ca^2+ is the primary signaling molecule that determines cell fate,including cell differentiation and cell death.Intercellular communication is also dependent on the transmission of Ca^2+ signaling.In recent years,a novel intercellular communication in animals has been reported that links individual cells and selectively promotes communication between distant cells and nearby cells.These highly sensitive nanometers with tubular structure are called tunneling nanotubes (TNT),and the human retinal pigment epithelial (RPE) cell line Arpe-19 has TNT to exchange molecular information between cells,and Ca^2+ imaging technology can be used to monitor the process.It shows that intercellular calcium signaling is transmitted through TNT,and human RPE cells communicate through tunneling nanotubes,which provides a new way for communication between RPE cells.Therefore,research is needed to transfer calcium ions through tunnel nanotubes between cells in the future.