坎地沙坦联合二甲双胍治疗轻中度肥胖型高血压伴左心室肥厚患者的临床疗效

Clinical efficacy of Candesartan combined with Metformin in the treatment of mild to moderate obesity with left ventricular hypertrophy

目的观察坎地沙坦与二甲双胍联合治疗轻中度肥胖型高血压伴左心室肥厚患者的临床疗效。方法选取我院2014年1月—2018年5月接收的轻中度肥胖型高血压伴左心室肥厚患者69例,随机分为试验组35例(给予坎地沙坦联合二甲双胍治疗),对照组34例(给予坎地沙坦治疗)。观察2组患者治疗前后收缩压、舒张压变化情况及血浆BNP水平,超声心动图测定E/A比值、左心室质量指数(LVMI)。结果试验组降压及BNP、E/A值、LVMI改善效果均优于对照组,差异具有统计学意义(P<0.05)。结论对轻中度肥胖型高血压患者采取坎地沙坦与二甲双胍联合治疗,能够达到降压、逆转左心室肥厚,改善左心功能的作用,临床疗效显著。

Objective To observe the clinical efficacy of candesartan combined with metformin in the treatment of mild to moderate obesity hypertension with left ventricular hypertrophy. Methods From January 2014 to May 2018, 69 patients with mild to moderate obesity hypertension with left ventricular hypertrophy were selected,35 patients were given candesartan plus metformin,and 34 patients in control group were only given candesartan treatment. The changes of systolic blood pressure,diastolic blood pressure and BNP before and after treatment were observed. The E/A ratio and left ventricular mass index (LVMI)were measured by echocardiography.Results The blood pressure,BNP,E/A and LVMI improvement effects of the experimental group were better than the control group,and the differences were statistically significant (P<0.05). Conclusion The combination of candesartan and metformin in patients with mild to moderate obesity can lower blood pressure,reverse cardiac remodeling,improve left ventricular function. The clinical effect is significant.