甲状腺自身抗体与慢性荨麻疹发生相关性的Meta分析

The association between thyriod autobodies and chronic urticaria:a Meta-analysis

目的:综合评价甲状腺自身抗体与慢性荨麻疹发生的相关性。方法:计算机检索The Cochrane Library、PubMed、The Web of Science、EMBase、CNKI、VIP、WanFang Data和Sinomed数据库,搜索有关甲状腺自身抗体与慢性荨麻疹相关性的研究,检索时限均为建库至2018年11月。由2名研究者独立筛选文献、提取资料并对纳入研究的文献进行质量评价,采用Stata 12.0软件进行Meta分析。结果:共纳入25个病例-对照研究,2224例慢性荨麻疹患者,1617例对照者。Meta分析结果显示:与对照组相比,抗甲状腺过氧化物酶抗体(TPO-Ab)阳性( RR =5.290,95 %CI:2.866- 9.766 , P <0.001)和抗甲状腺球蛋白抗体(TG-Ab)阳性( RR =6.229,95 %CI:3.737-10.383, P <0.001)增加慢性荨麻疹患者的发生风险。慢性荨麻疹组中TPO-Ab阳性率和TG-Ab阳性率差不多( OR =1.005,95 %CI:0.820- 1.227 , P =0.959)。亚组分析显示:地区分布及检测方法是结论的重要影响因素。结论:慢性荨麻疹的发病与甲状腺自身抗体存在相关性,但不同抗体之间和慢性荨麻疹的发生无明显差异。研究结果与分布地区和检测方法有关。

Objective:To systematically review the association between thyriod autobodies and chronic urticaria.Methods:The Cochrane Library、PubMed、the Web of Science、EMBase、CNKI、VIP、WanFang Data and Sinomed were searched to collect studies on the association between thyriod autobodies and chronic urticaria from inception to November, 2018. Two reviewers independently screened literature,extracted data and assessed the risk of bias of included studies, then meta-analysis was performed by using Stata 12.0 software.Results:A total of 25 case-control studies ,2224 chronic urticaria patients and 1617 controls were included. The results of Meta-analysis showed that ,compared with the control group, the positive rate of anti-thyroid peroxidase antibody [ OR =7.67, 95% CI (4.92~11.95), P <0.001] and the positive rate of anti-thyroglobulin antibody [ OR =7.77, 95% CI (4.55~13.26), P <0.001] significantly increased the risk of chronic urticaria. Anti-thyroid peroxidase antibody positive and anti-thyroglobulin antibody positive in the chronic urticaria group [ OR =1.08, 95% CI (0.87~1.35), P =0.499] aren't difference.Subgroup analysis shows that regional distribution and detection methods are important influencing factors.[WTHZ]Conclusions:Thyriod autobodies are associated with chronic urticaria,but there aren't significant difference between different antibodies and chronic urticaria. The results of the study are related to the distribution area and detection method.