结肠腺瘤复发率监测对早期癌发生的影响

The effect of the recurrence rate monitoring of colon adenoma on the incidence of early-stage cancer

目的:探讨结肠腺瘤复发率监测对早期癌发生的影响。方法:选择192例结肠腺瘤患者,以初次结肠镜为基线,单因素统计分析结肠腺瘤复发影响因素,并行多因素分析以找出结肠腺瘤复发的独立危险因素,探讨复发率监测对早期癌发生的影响。结果:192例结肠腺瘤患者,术后随访6~80个月,28例(14.58%)复发;腺瘤大小、腺瘤基底、腺瘤切除方式、腺瘤病理组织学分级是结肠腺瘤复发的影响因素(P<0.05),腺瘤大小、腺瘤病理组织学分级是结肠腺瘤复发的独立危险因素(P<0.05);在28例结肠腺瘤复发中,结肠癌发生率10.71%。结论:结肠腺瘤复发的独立危险因素为腺瘤大小、腺瘤病理组织学分级,通过监测结肠腺瘤复发者,可降低结肠癌发病率。

Objective:To explore the effect of the recurrence rate monitoring of colon adenoma on the incidence of early-stage cancer.Methods:192 patients with colon adenoma were selected. Univariate statistical analysis of factors affecting recurrence of colon adenomas with primary colonoscopy was made as the baseline and multivariate statistical analysis was made to determine independent risk factors for recurrence of colon adenoma, with the effect of recurrence rate monitoring on the incidence of early-cancer explored.Results:A total of 192 patients with colon adenoma were followed up for 6-80 months, with 28 patients (14.58 %) relapsing. Adenoma size, adenoma bases, ways of adenoma resection and adenoma histopathology were factors influencing the recurrence of colon adenoma ( P <0.05). The size and histopathological grade of adenomas were independent risk factors for recurrence of colon adenomas ( P <0.05). Among the 28 cases of colon adenoma recurrence, the incidence of colon cancer was 10.71 %.Conclusion:Independent risk factors for recurrence of colon adenomas are adenoma size and histopathological grading of adenomas. By monitoring the recurrence of colon adenomas, the incidence of colon cancer can be reduced.