不同剂量左旋甲状腺素对妊娠合并甲减患者胎儿发育的影响

Effects of different doses of levothyroxine on fetal development in patients with pregnancy combined with hypothyroidism

目的:探讨不同剂量左旋甲状腺素对妊娠合并甲减患者胎儿发育的影响。方法:将妊娠合并甲减孕妇112例分为两组,对照组应用低剂量左旋甲状腺素,观察组应用高剂量左旋甲状腺素。结果:观察组的总有效率高于对照组(P<0.05);治疗后观察组的FT3、FT4、TSH值与对照组对比差异有统计学意义(P<0.05)。观察组新生儿的智力发育与精神运动发育评分高于对照组(P<0.05)。结论:相对于低剂量,高剂量左旋甲状腺素治疗妊娠合并甲减患者能提高治疗效果,促进甲状腺激素分泌平衡,减少妊娠并发症的发生,促进新生儿的发育。

Objective:To investigate the effects of different doses of levothyroxine on fetal development in patients with pregnancy combined with hypothyroidism.Methods: 112 cases of pregnant women with hypothyroidism were selected and were equally divided into two groups. The control group was used with low dose of levothyroxine, and the observation group was used with high dose of levothyroxine.Results: The total effective rate of observation group were higher than that in the control group ( P <0.05). After treatment, the FT3, FT4 and TSH values in the observation group were significantly different from those in the control group ( P <0.05). The scores of mental development and psychomotor development in the observation group were significantly higher than those in the control group ( P <0.05).Conclusion: Compared with low dose, high dose of levothyroxine in the treatment of pregnant women with hypothyroidism can improve the therapeutic effect, promote the balance of thyroid hormone secretion, reduce the occurrence of pregnancy complications and promote the development of newborns.