不同术后干预方法治疗中重度宫腔粘连的临床研究

Different postoperative intervention approaches for the treatment of moderate-to-severe uterine adhesion: a clinical study

目的 探讨不同术后干预方法治疗中重度宫腔粘连的临床效果。方法 选择59例行宫腔粘连分离术治疗的中重度宫腔粘连患者,根据术后处理方法分为3组。Foley球囊组16例,术后采用Foley球囊导尿管干预;几丁糖组22例,术后采用医用几丁糖后联合Foley球囊导尿管干预;防粘连膜组21例,术后采用防粘连膜干预。比较3组患者术后1个月及3个月的治疗有效率。结果 术后1个月及3个月,三组患者疗效比较,差异均有统计学意义(P<0.05)。几丁糖组与防粘连膜组术后1个月及3个月的治疗有效率均高于Foley球囊组(均P<0.05),而几丁糖组与防粘连膜组术后1个月及3个月的治疗有效率比较,差异均无统计学意义(均P>0.05)。结论 中重度宫腔粘连患者行宫腔粘连分离术后,宫腔注入医用几丁糖+Foley球囊导尿管与放置防粘连膜均可有效预防宫腔再粘连。

Objective To explore the clinical effects of different postoperative intervention approaches on moderate-to-severe intrauterine adhesion. Methods Fifty-nine patients with moderate-to-severe intrauterine adhesion undergoing uterine adhesion separation were enrolled, and were divided into three groups according to the postoperative intervention approach. Sixteen cases in the Foley balloon group received postoperative intervention with Foley balloon urethral catheter;22 cases in the chitosan group received postoperative intervention with medical chitosan combined with Foley balloon urethral catheter;and 21 cases in the anti-adhesion membrane group received postoperative intervention with anti-adhesion membrane. The postoperative1 -and 3-month effective rates foRtreatment were compared among the three groups. Results One and 3 months afteRoperation, there were statistically significant differences in efficacy among the three groups ( P <0.05). The postoperative1 - and 3-month effective rates foRtreatment in the chitosan group and anti-adhesion membrane group were higheRthan those in the Foley balloon group ( all P <0.05 ), but there was no statistically significant difference between the chitosan group and the anti-adhesion membrane group in postoperative1 - oR3-month effective rate foRtreatment (all P >0.05 ). Conclusion EitheRintrauterine injection of medical chitosan plus Foley balloon urethral catheteRoRanti-adhesion membrane placement can effectively prevent intrauterine re-adhesion in patients with moderate-to-severe intrauterine adhesion afteRintrauterine adhesion separation.