地屈孕酮联合低分子肝素钙治疗先兆流产患者的效果

Effect of Dydrogesterone Combined with Low Molecular Weight Heparin Calcium in Patients with Threatened Abortion

目的探讨地屈孕酮联合低分子肝素钙治疗先兆流产患者的效果。方法选取2017年4月~2018年12月我院收治的先兆流产患者80例,按照随机数字表法分为对照组和研究组,各40例。对照组采用地屈孕酮进行治疗,研究组在对照组基础上联合低分子肝素钙进行治疗,比较两组妊娠结局及所产出新生儿不良结局。结果研究组早产、流产、正常足月妊娠占比分别为12.50%、7.50%、80.00%,优于对照组的30.00%、17.50%、52.50,差异有统计学意义(P<0.05)。研究组新生儿畸形、喘息急促、新生儿偏大、足月体重轻、正常新生儿占比分别为5.00%、10.00%、0、2.50%、82.50%,优于对照组的15.00%、22.50%、5.00%、10.00%、47.50%,差异有统计学意义(P<0.05)。结论地屈孕酮联合低分子肝素钙治疗先兆流产患者能够有效地改善患者的妊娠结局,减少新生儿畸形、喘息急促、新生儿偏大、足月体重轻等不良结局。

Objective To investigate the effect of dydrogesterone combined with low molecular weight heparin calcium in the treatment of patients with threatened abortion.Methods 80 patients with threatened abortion admitted to our hospital from April 2017 to December 2018 were enrolled.The patients were divided into the control group and the study group according to the random number table method,40 cases each.The control group was treated with dydrogesterone.The study group was treated with low molecular weight heparin calcium on the basis of the control group.The pregnancy outcomes of the two groups and the adverse outcomes of the newborns were compared.Results The preterm,abortion and normal term pregnancy proportions of the study group were 12.50%,7.50%,and 80.00%,respectively,which were better than the control group's 30.00%,17.50%,and 52.50,the difference was statistically significant (P<0.05),neonatal malformations,wheezing,neonatal hyperplasia,full-term weight,and normal neonatal proportions in the study group were 5.00%,10.00%,0,2.50%,and 82.50%,15.00%,22.50%,5.00%,10.00%,47.50% better than the control group,the difference was statistically significant(P<0.05).Conclusion Dydrogesterone combined with low molecular weight heparin calcium in patients with threatened abortion can effectively improve the pregnancy outcome of patients,and reduce adverse outcomes such as neonatal malformation,wheezing,neonatal hyperplasia,and full-term weight.