附桂骨痛片联合艾瑞昔布片及氟比洛芬巴布膏治疗膝骨关节炎的临床研究

Clinical Study on Treatment of Knee Osteoarthritis with Fuguigutong Tablets Combined with Ericoxib Tablets and Flurbiprofen Bab Cream

目的观察附桂骨痛片联合艾瑞昔布片和氟比洛芬巴布膏治疗膝骨关节炎(KOA)的临床疗效和安全性。方法选取2017年7月~2018年5月在我院就诊的KOA患者284例,按照随机数字表法分为A组和B组,各142例。A组患者给予口服艾瑞昔布片联合外用氟比洛芬巴布膏治疗,B组患者在A组基础上加服附桂骨痛片,两组患者均以8周为1个疗程。比较两组患者治疗前后的临床疗效及西安大略和麦克马斯特大学量表(WOMAC)评分、视觉模拟评分法(VAS)评分、中医证候评分、实验室检查指标、不良反应发生情况。结果B组治疗总有效率高于A组(90.14%vs77.46%),差异有统计学意义(P<0.05)。治疗后,两组患者WOMAC评分、VAS评分、中医证候积分,以及CRP、ESR、MMP-1、MMP-3水平均低于治疗前,且B组低于A组,差异均有统计学意义(P<0.05)。治疗中两组患者均无明显不良反应发生。结论附桂骨痛片联合艾瑞昔布片及氟比洛芬巴布膏可缓解关节疼痛,改善KOA患者临床症状,临床疗效好,且安全性高。

Objective To observe the clinical efficacy and safety of Fuguigutong Tablets combined with ericoxib tablets and flurbiprofen bab cream in the treatment of knee osteoarthritis (KOA).Methods A total of 284 patients with KOA who were admitted to our hospital from July 2017 to May 2018 were enrolled.According to the random number table,they were divided into group A and group B,each with 142 cases.Patients in group A were treated with oral ericoxib tablets combined with topical flurbiprofen bab cream.Group B was additionally given Fuguigutong tablets.All patients were treated with 8 weeks as a course of treatment.The clinical efficacy of the two groups of patients before and after treatment and the Western Ontario and McMaster University Scale (WOMAC) score,visual analog scale (VAS) score,TCM syndrome score,laboratory test indicators,adverse reactions occurred.Results The total effective rate of group B was higher than that of group A (90.14% vs 77.46%),the difference was statistically significant (P<0.05).After treatment,the WOMAC score,VAS score,TCM syndrome score,and CRP,ESR,MMP-1,and MMP-3 levels in the two groups were lower than those before treatment,and the group B was lower than the group A,the difference was statistically significant (P<0.05).There were no significant adverse reactions in the two groups of patients during the treatment.Conclusion The combination of Fuguigutong tablets combined with irbisoxib tablets and flurbiprofen bab cream can relieve joint pain,improve clinical symptoms of KOA patients,and has good clinical efficacy and high safety.