全血微量元素与手足口病的相关性研究

Investigation on relationship between whole blood trace elements and hand-foot-mouth disease

目的探讨全血微量元素水平变化与手足口病之间的关系,为手足口病的治疗及预防寻找具有临床应用价值的方法。方法选取2014年1月至2017年12月来广州市妇女儿童医疗中心诊治并确诊为手足口病毒感染的儿童80例纳入观察组。其中50例为EV71病毒感染,30例为柯萨奇病毒A16型(CAV16)感染。选取同期健康体检的80例儿童作为健康对照组,用原子吸收光谱法检测全血铁、钙、锌、镁及铜5种微量元素水平。两组数据进行比较。结果手足口病组患儿血锌、血钙和血铁的水平明显比健康对照组降低,两者之间比较有统计学意义,血铜以及血镁的水平比较没有显著性差异;相同年龄段的两组数据比较,血锌、血钙和血铁的水平明显比健康对照组降低(P<0.05),血铜以及血镁的水平比较没有显著性差异。感染EV71组儿童血锌水平明显低于感染CAV16组,血铜也低于CAV16组。结论儿童全血锌、铁元素和血钙水平低下可能手足口病相关。EV71引起的手足口病血铜有所下降也值得注意。

Objective To investigate the relationship between whole blood trace elements and hand-foot-mouth disease,and to find a clinical and practical treatment and prevention method for hand foot mouth disease.Methods eighty patients with hand-foot-mouth disease were enrolled in the observation group and contemporaneous eighty healthy children served as the control group.Then the concentrations of trace elements were detected by using atomic absorption spectroscopy.Results Compared with the healthy control group,the levels of whole blood zinc,iron and calcium in different age periods of HFMD group were significantly decreased with statistical difference( P <0.05).The levels of whole blood copper and magnesium have no statistical difference.The levels of whole blood zinc in children with HFMD caused by EV71 is lower than those caused by CAV16;The levels of whole blood copper in children with HFMD caused by EV71 is little lower than those caused by CAV16.Conclusion The decrease of whole blood zinc,iron and calcium levels in children may be associated with HFMD,We should pay attention to the decrease of whole blood copper in the patients with HFMD caused by EV71.