淋巴细胞比值与凝血参数对恶性肿瘤患者血液高凝状态的诊断影响分析

Analysis of the influence of lymphocyte ratio and coagulation parameters on the diagnosis of hypercoagulable state in patients with malignant tumor

目的分析研究淋巴细胞比值(NLR)与凝血参数对恶性肿瘤患者血液高凝状态的诊断影响。方法选择2015年6月1日到2018年6月1日该院收治的25例恶性肿瘤患者与25例良性肿瘤患者,将恶性肿瘤患者分为高凝亚组(n=10)与非高凝亚组(n=15),选取同期25例进行健康体检人员作为对照组,对中性粒细胞计数(NC)、淋巴细胞计数(LY)、NLR、D-二聚体(D-D)、纤维蛋白原(Fib)、血小板计数(PLT)、血小板压积(PCT)等情况进行比较分析,同时计算NLR、凝血参数诊断恶性肿瘤的灵敏度与特异性。结果恶性肿瘤患者NC、NLR、D-D与Fib水平明显高于对照组与良性肿瘤患者,LY、PLT与PCT水平明显低于对照组与良性肿瘤患者,差异显著(P<0.05);高凝亚组的NC、NLR、D-D与Fib水平明显高于非高凝亚组,LY、PLT与PCT水平明显低于非高凝亚组,差异显著(P<0.05);NLR与凝血参数诊断恶性肿瘤的灵敏度与特异性明显较高(P<0.05)。结论恶性肿瘤患者在血液高凝状态下的淋巴细胞比值明显升高,凝血参数存在显著的异常情况,并且NLR与凝血参数诊断恶性肿瘤的灵敏度与特异性明显较高。

Objective To analyze the effect of lymphocyte ratio (NLR) and coagulation parameters on the diagnosis of hypercoagulable state in patients with malignant tumors.Methods 25 patients with malignant tumors and 25 patients with benign tumors admitted to our hospital from June 1,2015 to June 1,2018 were enrolled.The patients with malignant tumors were divided into high-coagulation subgroups ( n =10) and non-high.Condensed subgroup ( n =15),Twenty-five healthy people were selected as control group.The sensitivity and specificity of neutrophil count (NC),lymphocyte count (LY),NLR,D-dimer (D-D),fibrinogen (Fib),platelet count (PLT) and platelet hematocrit (PCT) in the diagnosis of malignant tumors were compared.Results The levels of NC,NLR,DD and Fib in patients with malignant tumors were significantly higher than those in the control group and benign tumors.The levels of LY,PLT and PCT were significantly lower than those in the control group and benign tumors ( P <0.05).The levels of NC,NLR,DD and Fib in the subgroup were significantly higher than those in the non-hypercoagulated subgroup.The levels of LY,PLT and PCT were significantly lower than those in the non-hypercoagulated subgroup ( P <0.05).NLR and coagulation parameters were used to diagnose malignant tumors.The sensitivity and specificity were significantly higher( P <0.05).Conclusion The ratio of lymphocytes in hypercoagulable state of patients with malignant tumors is significantly increased.There are significant abnormalities in coagulation parameters,and the sensitivity and specificity of NLR and coagulation parameters for the diagnosis of malignant tumors are significantly higher.