临床常用药物对血肌酐检测的影响

Effect of drugs commonly used in clinical practice on serum creatinine detection

归纳总结临床常用药物对血肌酐检测结果的影响,为正确评估肾脏功能提供参考。计算机检索中国知网、万方数据库、维普期刊数据库、Pubmed数据库,获取药物对苦味酸法、肌氨酸氧化酶法及肾小管分泌有影响的相关文献,结合临床实践汇总分析。有研究显示酚磺乙胺、链霉素等对苦味酸法产生正向干扰;羟苯磺酸钙、酚磺乙胺、维生素C等对酶法产生负相干扰;西咪替丁、决奈达隆、可比斯他等影响肾小管对肌酐的分泌,产生假阳性结果。部分药物对血肌酐的测定结果有一定程度的干扰,临床诊断时需排除药物的影响。

The impact of common clinical drugs on serum creatinine test were summarized to provide correct evaluation of renal function.The articles about the effects on serum creatinine test of Jaffé reaction-rate method,sarcosine oxidase method and renal tubules affected by drugs were searched and identified from the databases of CNKI,Wanfang Med Online,VIP Database and Pubmed in combination with clinical practice.The positive interference was identified in Jaffé reaction-rate method by ethamsylate,streptomycin,etc.The negative interference was identified in sarcosine oxidase method by Calcium dobesilate,ethamsylate,vitamin C etc.A false positive result was observed as a result of some drugs inhibiting the secretion of creatinine,such as cimetidine,dronedarone,and cobicistat,etc.There was a certain degree of interference with the determination of serum creatinine by some drugs,and effective measures must be taken to eliminate the interference.