基于血液降钙素原水平检测的抗菌药物应用进展

Progress in the application of antibacterials based on the detection of blood procalcitonin concentration

抗菌药物滥用引起的细菌耐药日趋严重,若不加以遏制,势必将造成日后无药可用的局面。我国作为世界上抗菌药物滥用最为严重的国家之一,细菌耐药率明显高于其他欧美国家[1]。据中国CHINET细菌耐药监测网络的报告显示,临床分离菌对常用抗菌药物的耐药率仍呈增长趋势[2]。因此,如何管理与指导抗菌药物的使用是每一位微生物工作者应加以关注的问题。降钙素原(PCT)作为一种浓度随着细菌感染而升高的生物标志物,因其可用于预测脓毒症的发生、指导抗菌药物的使用等优点,是当下研究的热点之一。本文将对PCT指导抗菌药物使用的研究现状及其检测方法作一综述。

Drug resistance caused by antibacterial drug abuse is becoming more and more serious.It will inevitably lead to a situation in which there will be no drug use in the future if it is not contained.As one of the countries with the most serious antibacterial drug abuse in the world,the rate of bacterial resistance in China is significantly higher than that in other European and American countries.According to the report of CHINET bacterial resistance monitoring network in China,the resistance rate of clinical isolates to commonly used antibiotics is still increasing.[2] Therefore,how to manage and guide the use of antibiotics is a problem that every microbial worker should pay attention to.As a biomarker whose concentration increases with bacterial infection,procalcitonin (PCT) is one of the hotspots in current research because it can be used to predict the occurrence of sepsis and guide the use of antibiotics.In this paper,the research status and detection methods of PCT guiding the use of antibiotics are reviewed.