循环外泌体在酮病奶牛肝脏脂代谢紊乱中的生理作用

Physiological Role of Circulating Exosomes on Hepatic Lipid Metabolism Disorder in Ketosis Dairy Cows

奶牛酮病是由能量负平衡引起的,是围产期常见代谢紊乱性疾病。外泌体是含有膜蛋白、封闭胞质蛋白和RNA的磷脂双分子层的膜泡,可以传递信息并调节机体细胞的生理状态。本文就循环外泌体对奶牛肝脏脂代谢的影响、对腺苷酸活化蛋白激酶α/沉默信息调节因子1(AMPKα/SIRT1)通路的调节作用,以及作为酮病奶牛肝脏脂代谢紊乱诊断标志物的研究现状进行综述,有助于探究奶牛循环外泌体对酮病奶牛肝脏脂代谢紊乱的修复效果和作用机制,为寻找合适的酮病靶向治疗药物提供理论和实践依据。

Dairy cows ketosis is caused by negative energy balance and is a common metabolic disorder in perinatal period. The exosomes are a class of vesicles containing membrane proteins,blocked cytoplasmic proteins and RNA,which can transmit information to regulate the physiological state of the body cells. This article reviewed that circulating exosomes exert an influence on liver lipid metabolism in dairy cows,regulate adenosine5’-monophosphate-activated protein kinase α/silencing signal regulator 1( AMPKα-SIRT1) pathway,and act as diagnostic markers for hepatic lipid metabolism disorders in ketosis cows. To sum up,this reviewof the current research status is helpful to explore the repairing effect and mechanism of circulating exosomes on hepatic lipid metabolism disorder in ketosis cows,and provides theoretical and practical basis for finding suitable targeted drugs for ketosis.