高血压儿童青少年肥胖与颈动脉内中膜厚度的关系

Association between obesity and carotid intima-media thickness in hypertensive children and adolescents

目的探讨儿童青少年肥胖与颈动脉内中膜厚度(carotid intima-media thickness, cIMT)的关系,为儿童青少年心血管疾病预防提供依据。方法采用方便整群抽样方法选取济南市城区289名6~17岁中小学生,测量身高、体重、血压和cIMT,并采用Logistic回归模型分析肥胖和cIMT的关系。结果男生肥胖组cIMT水平和增厚检出率均高于非肥胖组(P值均<0.05);女生肥胖组与非肥胖组cIMT水平和增厚检出率差异无统计学意义(P值均>0.05);调整性别、年龄和血压后,多因素Logistic回归分析表明,总人群肥胖组cIMT增厚风险OR值及95%CI为3.03(95%CI=1.11~8.28);男女生肥胖组OR值及95%CI为4.32(95%CI=1.23~15.21),1.45(95%CI=0.23~9.37)。结论肥胖可能增加儿童青少年的cIMT水平和cIMT增厚检出率。应采取有效措施预防和控制儿童青少年肥胖,降低儿童青少年血管结构异常风险。

Objective To examine the relationship between obesity and carotid intima-media thickness(cIMT) in children and adolescents in order to provide scientific evidence for the prevention and control of cardiovascular diseases. Methods A total of 289 children and adolescents aged 6 to 17 years were included in the study, and weight, height, blood pressure and cIMT were measured. Multivariable Logistic regression model was used to analyze the relationship between obesity and cIMT. Results The level of cIMT and prevalence of high cIMT in obese males were higher than those in non-obese males(P<0.05), while there was no statistical significance between two weight groups in females(P>0.05). After adjusted for sex, age and blood pressure, compared with the non-obese children and adolescents, the odds ratios(ORs) of obesity for high cIMT in total sample, males and females were 3.03(95%CI=1.11-8.28), 4.32(95%CI=1.23-15.21) and 1.45(95%CI=0.23-9.37) respectively. Conclusion Obesity may increase cIMT levels and risk of high cIMT in children and adolescents. Effective measures should be taken to prevent and control the obesity, and to reduce the risk of abnormal vascular structure in children and adolescents.