PKNOx2及相关基因在胃癌中的作用机制研究进展

The mechanism of PBX/Knotted homeobox 2 and related genes in gastric cancer

PKNOX2是一种转录因子,在胚胎时期脏器的形成中发挥重要作用,在正常成年人的部分脏器中也有表达,并参与生长发育过程.同时,PKNOX2通过促进肿瘤细胞凋亡、抑制增殖、阻断上皮细胞间质化等过程具有抑癌基因作用.在胃癌(GC)中PKNOX2通过激活胰岛素样生长因子结合蛋白5(IGFBP5)和p53信号通路发挥抑癌作用,其过表达上调RPRM、BTG2、GADD45A、p73等多个基因,被上调的基因可协同PKNOX2发挥抑癌作用.本文介绍PKNOX2及相关基因在胃癌中抗肿瘤作用的机制.

PBX/Knotted Homeobox 2 (PKNOX2) is a transcription factor, which plays an important role in the formation of organs during the embryonic period, and is also expressed in some organs of normal adults, and is involved in the growth and development process.At the same time, PKNOX2 has the effect of tumor suppressor gene by promoting tumor cell apoptosis, inhibiting proliferation and blocking epithelial-to-mesenchymal transition, etc.In gastric cancer (GC), PKNOX2 plays a tumor suppressor role by activating the IGFBP5 and p53 signaling pathways, and its overexpression upregulates multiple genes, such as RPRM, BTG2, GADD45A and p73, etc., and the up-regulated genes can synergistically play a tumor suppressor role with PKNOX2.This article introduces the mechanism of PKNOX2 and related genes in the anti-tumor effect of gastric cancer.