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三氧化二砷在宫颈癌治疗中的应用研究进展 被引量:1

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摘要 2012年全球约有53万宫颈癌新发病例及27万例死亡[1-2]。其中95%的病例是由高危型人乳头瘤病毒(HPV)持续感染引起[3]。自从三氧化二砷(arsenic trioxide,As2O3)展现出在治疗急性早幼粒细胞白血病中的显著疗效后,其在抗肿瘤方面的作用也不断被报道和证实[4-5]。
出处 《中国实用妇科与产科杂志》 CAS CSCD 北大核心 2019年第7期833-835,共3页 Chinese Journal of Practical Gynecology and Obstetrics
基金 四川省医学重点学科和重点专科建设(川卫办发[2007]407号)
关键词 宫颈肿瘤 三氧化二砷 人乳头瘤病毒 纳米药物载体 脂质体 cervical tumor As2O3 HPV Nano-drug carrier lipidosome
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  • 1ZHOU Jin1,MENG Ran1,2,SUI Xinhua2,LI Wenbin3 & YANG Baofeng1 1.The First Hospital of Harbin Medical University,Harbin 150001,China,2. Shijitan Hospital,The Ninth Clinical Medical College of Peking University,Beijing 100038,China,3. Xuanwu Hospital,Capital University of Medical Sciences,Beijing 100053,China.Various tolerances to arsenic trioxide between human cortical neurons and leukemic cells[J].Science China(Life Sciences),2006,49(6):567-572. 被引量:6
  • 2谢良喜,李德锐,林英城,林昆,陈炯玉,洪超群.三氧化二砷对鼻咽癌离体细胞的放射增敏作用[J].中华放射医学与防护杂志,2004,24(3):240-242. 被引量:13
  • 3Kinjo K,Kizaki M,Muto A,et al.Arsenic trioxide (As2O3)-induced apoptosis and differentiation in retinoic acid-resistant acute promyelocytic leukemia model in hGM-CSF-produ.cing transgenic SCID mice[J].Leukemia,2000; 14(3):431-438
  • 4Roboz GJ,Dias S,Lam G,et al.Arsenic trioxide induces dose-and time-dependent apoptosis of endothelium and may exert an antiletnkemia effect via inhibitition of angiogenesis[J].Blood,2000; 96(4):1525 -1530
  • 5Zhu Q,Zhang JW,Zhu HQ,et al.Synergic effects of arsenic trioxide and cAMP during acute promyelocytic leukemia cell maturation subtends a movel signaling cross-talk[J].Blood,2002;99(3):1014-1022
  • 6马军,邱林.诱导分化在恶性肿瘤及白血病治疗中的应用[J].实用医院临床杂志,2007,4(6):3-6. 被引量:4
  • 7Parkin DM,Bray F,Ferlay J. Global cancer statistics,2002[J].CA:A Cancer Journal for Clinicians,2005,(02):74-108.doi:10.3322/canjclin.55.2.74.
  • 8Yu J,Qian HL,Li Y F. Arsenic trioxide (As2O3) reduces the invasive and metastatic properties of cervical cancer cells in vitro and in vivo[J].Gynecologic Oncology,2007,(02):400-406.doi:10.1016/j.ygyno.2007.04.016.
  • 9Bae-Jump VL,Zhou CX,Boggess JF. Arsenic trioxide (As2O3) inhibits expression of estrogen receptoralpha through regulation of the mitogen-activated protein kinase(MAPK) pathway in endometrial cancer cells[J].Reproductive Sciences,2008,(10):1011-1017.doi:10.1177/1933719108324134.
  • 10Ellen T,Ke Q,Zhang P. NDRG1,a growth and cancer related gene:regulation of gene expression and function in normal and disease states[J].Carcinogenesis,2008,(01):2-8.

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