急性支气管哮喘患儿血清LTB4、IL-17水平和肺功能的变化及意义

Changes and Significance of Serum LTB4 , IL-17 Levels and Pulmonary Function in Children with Acute Bronchial Asthma

【目的】探讨急性支气管哮喘患儿血清白三烯B4(LTB4)、白介素17(IL-17)和肺功的能变化及临床意义。【方法】在本院治疗的急性哮喘患儿共90例,依据病情严重度分为轻度组、中度组和重度组。选择健康儿童30例作为对照组。比较四组血清LTB4、L-17、IgE水平和肺功能情况。【结果】轻度、中度及重度哮喘组患儿的血清IL-17、LTB4和IgE水平随哮喘程度的加深逐渐增高,且以重度组患儿的相关数值上升最为显著,各组之间相比较差异均有显著性(P <0.05)。除轻度组与对照组的LTB4水平比较差异无显著性(P >0.05),三组不同程度哮喘患儿各指标水平均明显高于对照组,且差异均有显著性(P <0.05)。轻度组、中度组和重度组患儿的第一秒钟用力呼气量(FEV1)/用力肺活量(FVC)的比值(FEV1%),最大呼气流量(PEF),50%、25%肺活量最大呼气流速(V50、V25)水平随哮喘程度的加深逐渐降低,且以重度组患儿的肺功能相关数值降低最为显著,各组间相比较差异均有显著性(P<0.05)。【结论】急性支气管哮喘患儿血清LTB4 、L-17水平明显增加,PEF、FEV1、V50,V25等肺功能指数明显下降,且与患儿病情严重程度相关。

[Objective] To investigate the functional changes and clinical significance of serum leukotriene B4 (LTB4), interleukin 17 (IL-17) and pulmonary function in children with acute bronchial asthma.[Methods] Ninety children with acute asthma were divided into mild group, moderate group and severe group according to the severity of the disease. Thirty healthy children were selected as control group. The levels of serum LTB4, IL-17, IgE and pulmonary function were compared among the four groups.【Results】 The serum levels of IL-17, LTB4 and IgE in the mild, moderate and severe asthma groups in creased gradually with the deepening of asthma, especially in the severe asthma group. There were significant differences among the groups ( P <0.05). There was no significant difference in the levels of LTB4 between the mild group and the control group ( P >0.05). The levels of each index in three groups of children with different degrees of asthma were significantly higher than those in the control group ( P <0.05). The ratio of forced expiratory volume (FEV1)/forced vital capacity (FVC) in the first second (FEV1 %), maximum expiratory flow (PEF), 50% and 25% vital capacity (V50, V25) of children in the mild, moderate and severe groups gradually decreased with the deepening of asthma, and the correlation value of lung function in the severe group decreased most s*ignificantly with significant differences among the groups ( P <0.05).[Conclusion] The serum levels of LTB4 and IL-17 in children with acute bronchial asthma are significantly increased, and the pulmonary function indexes such as PEF, FEV1 %, V50% and V25 % were significantly decreased, which is related to the severity of the disease.