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乌司他丁治疗脑出血并肺部感染患者的疗效及对炎性细胞因子水平的影响 被引量:6

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摘要 【目的】探讨乌司他丁治疗脑出血并肺部感染患者的临床疗效及对炎性细胞因子水平的影响。【方法】68例脑出血肺内感染患者随机分为两组,对,服组采用常规对症治疗,观察组在常规治疗基础上联合乌司他丁治疗,比较两组临床疗效。【结果】观察组患者总有效率为94.12%(32/34),高于对照组的76.47%(26/34),且两组比较差异有显著性(P<0.05)。观察组患者治疗后总抗氧化能力(T-AOC),谷胱甘肽过氧化物酶(GSH-Px)水平高于,肿瘤坏死因子-α(TNF-α)、白介素-1β( IL-1β),降钙素原(PCT),和肽素水平低于对照组(P<0.05);但卒中量表(NIHSS)评分与对照组比较差异无显著性(P>0.05)。【结论】乌司他丁治疗脑出血肺内感染疗效显著,其机制可能与降低TNF-α、IL-1β、PCT水平,提高T-AOC、GSH-Px水平有关。
出处 《医学临床研究》 CAS 2019年第6期1197-1199,共3页 Journal of Clinical Research
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