基于超分子“印迹模板”整合分析中药“十八反”配伍禁忌

Integrated analysis of “eighteen incompatible medicaments” of Chinese materia medica based on supramolecular imprinting interaction

"十八反"是传统中药配伍禁忌的重要内容,涉及中药临床用药安全有效的关键基础问题。在前期提出的中医药超分子"印迹模板"自主作用规律的基础上,以中药"十八反"反药对为对象,对其当前研究基础进行整合分析。首先分析总结了中药"十八反"的历史沿革,再运用超分子"印迹模板"解析中药配伍:中药配伍是将2种或2种以上中药有效成分群(客体分子)之间以非共价键进行结合,形成新的超分子体系,再与人体(主体分子)发生印迹作用,按"印迹模板"产生药效与毒效,宏观上表现出中药的配伍规律。基于此,再从超分子化学角度分别对"十八反"各组药对进行整合分析,最后提出了"十八反"的化学动力学、网络动力学、谱毒效动力学逐层推进的超分子毒与效整合研究方法,以期为"十八反"配伍禁忌机制研究提供思考和借鉴,为临床应用提供参考。

The "eighteen incompatible medicaments" is an important content of Chinese materia medica (CMM) compatibility contraindication, involving the key basic problem of safe and effective clinical use of CMM. Based on the rule of the automatic action of supramolecular "imprinting template" previously proposed, the current research basis of "eighteen incompatible medicaments" were integrated and analyzed. Firstly, the history of "eighteen incompatible medicaments" were summarized, then the theory of Chinese materia medica (CMM) compatibility was interpreted by supramolecular "imprinting template":the compatibility of CMM are that two or more than two kinds of CMM effective components group of molecules (object) are combined by non-covalent bonds, and the new formed supramolecular system and the human body (subject) are interacted with each other according to "imprinting template", and then the toxicity and efficacy were generated, while the compatibility law of CMM is displayed macroscopically. Based on this, three groups of "eighteen incompatible medicaments" were discussed from the perspective of supramolecular chemistry, and the supramolecular method integrating toxicity with efficacy was put forward, including "chemicalkinetics","network kinetics" and "spectrum toxicity and efficacy kinetics" methods, thereby providing the ideas and reference for the research on the mechanism of "eighteen incompatible medicaments" and providing reference for clinical application.