新生儿早发型GBS疾病危险因素与预防策略

Risk factors and prevention strategies of early-onset GBS disease in neonates

新生儿早发型GBS疾病(GBS-EOD)指发病于生后1周内(0~6d)的GBS感染性疾病,占新生儿GBS疾病的80%,起病急、病情进展快,主要表现为肺炎、脓毒血症,部分可合并化脓性脑膜炎。是西方国家新生儿高致病性和高致死性疾病的主要原因,近年来在我国发病率有增高趋势。本文作者对该病的危险因素和预防策略进行综述,旨在早期识别该病,及时采取合理预防措施减少该病发病率。

Early-onset GBS disease (GBS-EOD) refers to the infectious disease of GBS that occurs within one week (0~6 d) after birth, accounting for 80% of GBS disease in newborns. The disease is acute and progresses rapidly. The main manifestations of GBS are pneumonia and sepsis, and some of them may be complicated with purulent meningitis. Early-onset GBS disease is the main cause of neonatal high pathogenicity and mortality in Western countries. In recent years, the incidence of GBS disease in China has increased. This article reviews the risk factors and preventive strategies of the disease, aiming at early identification of the disease and timely adoption of reasonable preventive measures to reduce the incidence of the disease.