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Shh信号通路在抗恶性肿瘤治疗中的机制研究 被引量：7

Advances in the mechanism of Shh signaling pathway in anti-malignant tumor therapy
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摘要 恶性肿瘤是危害中国居民健康的疾病之一,其每年发病数和死亡数分别占全球的23.7%和30%。由于人口老龄化、工业化和生活方式的改变等原因,我国恶性肿瘤的发病数和死亡数仍持续增加,严重威胁着广大患者的健康和生命[1]。因此,深入研究肿瘤浸润、转移的分子机制,发现有效治疗靶点对于改善患者预后具有极其重要的意义。研究发现Shh(Sonic hedgehog,Shh)信号通路与多种肿瘤的形成有着密切的关系,Shh在基底细胞癌、卵巢癌.
作者 谢子朋 王芳 朱毅 XIE Zi-peng;WANG Fang;ZHU Yi(Basic Medical College of Tianjin Medical University,Tianjin 300070,China)
机构地区 天津医科大学基础医学院 天津医科大学第二医院妇产科
出处 《中国实用内科杂志》 CAS CSCD 北大核心 2019年第7期653-655,共3页 Chinese Journal of Practical Internal Medicine
基金 天津市自然科学基金(18JCYBJC28000)
关键词 肿瘤 侵袭 转移 刺猬基因 cancer invasion metastasis hedgehog gene
分类号 R730 [医药卫生—肿瘤]
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  • 1Omenetti, Alessia,Porrello, Alessandro,Jung, Youngmi,Yang, Liu,Popov, Yury,Choi, Steve S,Witek, Rafal P,Alpini, Gianfranco,Venter, Juliet,Vandongen, Hendrika M,Syn, Wing-Kin,Baroni, Gianluca Svegliati,Benedetti, Antonio,Schuppan, Detlef,Diehl, Anna Mae.Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans[J]. Journal of Clinical Investigation . 2008 (10)
  • 2Sunil R. Hingorani,Lifu Wang,Asha S. Multani,Chelsea Combs,Therese B. Deramaudt,Ralph H. Hruban,Anil K. Rustgi,Sandy Chang,David A. Tuveson.Trp53 R172H and Kras G12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice[J]. Cancer Cell . 2005 (5)
  • 3Lei Zheng,Jing Xue,Elizabeth M. Jaffee,Aida Habtezion.Role of Immune Cells and Immune-Based Therapies in Pancreatitis and Pancreatic Ductal Adenocarcinoma[J].Gastroenterology.2013(6)
  • 4Karl Quint,Manuel Tonigold,Pietro Di Fazio,Roberta Montalbano,Susanne Lingelbach,Felix Rückert,Beate Alinger,Matthias Ocker,Daniel Neureiter.Pancreatic cancer cells surviving gemcitabine treatment express markersof stem cell differentiation and epithelial-mesenchymal transition[J].International Journal of Oncology.2012(6)
  • 5Shih-Hui Li,Junsheng Fu,Dara Nall Watkins,Rakesh K. Srivastava,Sharmila Shankar.Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog–GLI pathway[J].Molecular and Cellular Biochemistry.2013(1)
  • 6Charlie Lees,Sarah Howie,R. Balfour Sartor,Jack Satsangi.The Hedgehog Signalling Pathway in the Gastrointestinal Tract: Implications for Development, Homeostasis, and Disease[J].Gastroenterology.2005(5)
  • 7Ilya Gukovsky,Ning Li,Jelena Todoric,Anna Gukovskaya,Michael Karin.Inflammation, Autophagy, and Obesity: Common Features in the Pathogenesis of Pancreatitis and Pancreatic Cancer[J].Gastroenterology.2013(6)
  • 8Andrew D. Rhim,Emily T. Mirek,Nicole M. Aiello,Anirban Maitra,Jennifer M. Bailey,Florencia McAllister,Maximilian Reichert,Gregory L. Beatty,Anil K. Rustgi,Robert H. Vonderheide,Steven D. Leach,Ben Z. Stanger.EMT and Dissemination Precede Pancreatic Tumor Formation[J].Cell.2012(1)
  • 9Pietro Di Fazio,Roberta Montalbano,Karl Quint,Beate Alinger,Ralf Kemmerling,Tobias Kiesslich,Matthias Ocker,Daniel Neureiter.The pan?deacetylase inhibitor panobinostat modulates the expressionof epithelial?mesenchymal transition markers in hepatocellular carcinoma models[J]. Oncology Letters . 2013 (1)
  • 10Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer[J]. Cancer Cell . 2011 (4)

共引文献653

同被引文献55

引证文献7

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中国实用内科杂志
2019年 第7期

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