新型庚酰基吡唑啉酮的合成及晶体性能表征

Synthesis and Performance Exploration of Pyrazolone Derivatives

本文以1-苯基-3-甲基-吡唑啉酮-5(PMP)含氮五元杂环为母体,选取含7个碳的直链烃为取代基,采用Jensen合成法,合成出新型的吡唑啉酮衍生物1-苯基-3-甲基-4-庚酰基吡唑啉酮-5(HL).应用元素分析对产物进行组成测试,并将获得的单晶在单晶XRD衍射仪内进行结构分析,发现晶体属于单斜晶系,空间群为P 21/c,晶胞参数a,b,c分别为0. 850 02(9),0. 840 90(9),2.223 6(2) nm,晶胞中独立原子的个数Z=4,品质因子S=1.082.同时运用热重分析、红外光谱分析和荧光光谱对其进行表征,并对其电化学性能和生物学特性进行了探索.

A novel pyrazolone derivative,1-phenyl-3-methyl-4-heptanoyl pyrazolone-5( HL),was synthesized by Jensen synthesis method,using 1-phenyl-3-methyl-4-heptanoyl pyrazolone-5( PMP) as the parent and seven carbon-containing straight-chain hydrocarbons as substituents. The composition of the product was tested by elemental analysis,and the structure of the obtained single crystal was analyzed by single crystal XRD diffractometer. It was found that the crystal belong to monoclinic system,space group is P 21/c,cell parameters a,b and c were 0.850 02(9),0.840 90(9),2.223 6(2) nm,the number of independent atoms Z in a structure cell was 4,the quality factor S was 1.082,respectively. At the same time,it is characterized by thermogravimetric analysis,infrared spectroscopy and fluorescence spectroscopy,and its electrochemical and biological properties are also explored.