Synthesis, Crystal Structure and Fungicidal Activity of Ethyl 2-(3-(4-Fluorobenzamido)phenyl)-4-((4-fluorobenzoyl)oxy)thiazole-5-carboxylate

The target compound,ethyl 2-(3-(4-fluorobenzamido)phenyl)-4-((4-fluorobenzoyl)oxy)thiazole-5-carboxylate,was synthesized by four-step procedures including N-protection,thionation,cyclization and acylation.Its structure was characterized by 1 H NMR,13C NMR,HRMS and single-crystal X-ray diffraction.The target compound crystallizes as monoclinic crystal system,space group C2/c with a=9.6097(19),b=14.246(3),c=33.070(7)A,V=4515.1(16)A3,Z=8.Dc=1.496 Mg/m3,F(000)=2096 andμ=0.203 mm-1.There are 21864 reflections measured(4.94≤2θ≤55.96°),of which 5357 were unique(Rint=0.1418)and used in all calculations.The final R=0.0581(I>2δ(I))and wR=0.1453(reflections).The target compound showed over 50%of growth inhibition against Physalospora piricola,Rhizoctonia cere al is and Sclerotinia sclerotiorum.

The target compound, ethyl 2-（3-（4-fluorobenzamido）phenyl）-4-（（4-fluorobenzoyl）oxy） thiazole-5-carboxylate, was synthesized by four-step procedures including N-protection, thionation, cyclization and acylation. Its structure was characterized by 1 H NMR, 13C NMR, HRMS and single-crystal X-ray diffraction. The target compound crystallizes as monoclinic crystal system, space group C2/c with a = 9.6097（19）, b = 14.246（3）, c = 33.070（7） ?, V = 4515.1（16） ?3, Z = 8, Dc = 1.496 Mg/m3, F（000） = 2096 and μ = 0.203 mm-1. There are 21864 reflections measured（4.94≤2θ≤55.96°）, of which 5357 were unique（Rint = 0.1418） and used in all calculations. The final R = 0.0581（I > 2σ（I）） and wR = 0.1453（reflections）. The target compound showed over 50% of growth inhibition against Physalospora piricola, Rhizoctonia cerealis and Sclerotinia sclerotiorum.