精神分裂症患者家庭亲密度与适应性的Meta分析

Meta-analysis of family adaptability and cohesion of schizophrenia patients

目的探讨国内精神分裂症患者的家庭亲密度与适应性现状。方法系统检索中国知网(CNKI)、万方数据知识服务平台、维普中文科技期刊数据库(VIP)、中国生物医学文献数据库(CBM)、PubMed和Cochrane图书馆,检索时间为建库至2018年8月15日,纳入关于精神分裂症患者家庭功能的病例对照研究,并手工检索已发表的相关文献。两位研究者同时独立对纳入文献进行筛选和数据提取,采用Review manager 5.3对家庭亲密度与适应性进行分析。结果共纳入8篇文献,其中研究组678例,对照组780例。Meta分析结果显示,研究组实际亲密度[WMD=-5.13,95%CI(-7.64^-2.62),P<0.001]、实际适应性[WMD=-4.08,95%CI(-5.63^-2.52),P<0.001]和理想适应性[WMD=-3.50,95%CI(-6.43^-0.57),P=0.02]均低于对照组。两组的理想亲密度差异无统计学意义[WMD=-1.10,95%CI(-4.46~2.25),P=0.52];研究组的不满意亲密度高于对照组[WMD=3.07,95%CI(1.78~4.36),P<0.001];研究组的不满意适应性差异无统计学意义[WMD=1.51,95%CI(-0.23~3.24),P=0.09]。结论精神分裂症患者的家庭亲密度和适应性处于较低水平,需加强对患者家庭功能的关注。

Objective To explore the current situation of family adaptability and cohesion of patients with schizophrenia in China.Methods China National Knowledge Infrastructure(CNKI),WanFang Database,VIP Database,CBM,PubMed and Cochrane library were searched from database established to August 15,2018.Case-control studies on family function in patients with schizophrenia were included and the published literatures were manually searched.Two researchers independently screened and extracted the included literatures and analyzed their family adaptability and cohesion using Review manager 5.3 software.Results A total of 8 articles were included,including 678 in the study group and 780 in the control group.Meta-analysis results showed that the actual intimacy,actual adaptability and ideal adaptability of the study group were lower than the actual intimacy of the control group(WMD=-5.13,95%CI(-7.64--2.62),P<0.001),actual adaptability(WMD=-4.08,95%CI(-5.63--2.52),P<0.001)and ideal adaptability(WMD=-3.50,95%CI(-6.43--0.57),P=0.02),but there was no significant difference in the ideal intimacy(WMD=-1.10,95%CI(-4.46-2.25),P=0.52);the unsatisfactory intimacy of the study group was higher than the control group(WMD=3.07,95%CI(1.78-4.36),P<0.001),but there was no significant difference in unsatisfactory adaptability(WMD=1.51,95%CI(-0.23-3.24),P=0.09).Conclusion The family intimacy and adaptability of patients with schizophrenia are at a low level,and social and family need to strengthen the attention of patients'family function.