围产期静脉血栓形成预测方案的研究

Study on Peritoneal Venous Thrombosis Prediction Program

目的研究围产期静脉血栓形成预测方案。方法随机选择2016年7月-2017年12月在该院产检、分娩的具有围产期静脉血栓形成危险因素的孕妇1650例作为研究组,将出现临床表现、D-2聚体升高的产妇作为研究1组,共计37例,将未出现上述体征或者未出现D-2聚体升高的产妇作为研究2组,共计1 613例,随机选择同期产检在本院分娩的、没有危险因素的正常产检孕妇1 650名为对照组,所有孕妇均在产前及产后42 d给予D-2聚体检查、静脉血栓检查。比较研究组和对照组在孕妇产后42 d静脉血栓发生率,比较研究1组和研究2组在孕妇产后42 d静脉血栓发生率。结果研究组血栓形成率为0.18%,高于对照组0.12%,但差异无统计学意义(P>0.05),研究1组血栓形成率为0.00%,研究2组血栓形成率为0.18%,研究1组、研究2组及对照组患者围产期静脉血栓形成率不具有统计学差异(P>0.05),其中研究1组血栓形成率低研究2组,但差异无统计学意义(χ^2=2.853,P=0.091),研究2组血栓形成率高于对照组,差异无统计学意义(χ^2=0.001,P=0.980)。结论危险因素+临床症状+D-2聚体这一联合方案预测围产期静脉血栓形成风险具有重要的价值,可以指导临床进行合理的干预,预防围产期静脉血栓形成、降低孕产妇死亡率,有重大意义。

Objective To study the prediction program of perinatal venous thrombosis.Methods A total of 1650 pregnant women with perinatal venous thrombosis risk factors who were born in our hospital from July 2016 to December 2017 were selected as the study group.The clinical manifestations and maternal D-2 aggregates increased.As study group 1,a total of 37 patients,the women who did not have the above signs or did not appear D-2 polymer increased as a study group 2,a total of 1613 cases,random selection of the same period of birth check in the hospital,no risk factors normal 1650 pregnant women were selected as the control group,and all pregnant women were given D-2 polymer test and venous thrombosis before and after 42 days.The incidence of venous thrombosis in the study group and the control group at 42 days postpartum was compared between the study group and the study group 2 in the 42-day postpartum venous thrombosis.Results The thrombosis rate of the study group was 0.18%,which was higher than that of the control group (0.12%),but there was no statistical difference (P>0.05).The thrombosis rate of the study group was 0.00%,and the thrombosis rate of the study group 2 was 0.18%.There was no significant difference in perinatal venous thrombosis between the study group 1,the study group 2 and the control group (P>0.05).Among them,the study group 1 had a low rate of thrombosis,but there was no statistical difference (χ^2=2.853,P=0.091),the thrombosis rate of the study group 2 was higher than that of the control group,but there was no statistically statistical difference (χ^2=0.001,P=0.980).Conclusion The combination of risk factors + clinical symptoms + D-2 mers is of great value in predicting the risk of perinatal venous thrombosis,which can guide clinical interventions to prevent perinatal venous thrombosis and reduce maternal mortality.It is of great significance.