高压氧对脑梗死患者血脂及超声血液流变学的影响

Effects of hyperbaric oxygen on blood lipid and hemorheology in patients with cerebral infarction

目的探讨高压氧(HBO)对脑梗死患者血脂和超声血液流变学的影响。方法选取2014年2月—2016年2月在牡丹江医学院红旗医院诊疗的脑梗死患者120例,根据随机信封抽签原则分为HBO治疗(HBO)组和对照组,每组60例。对照组给予常规药物治疗;HBO组在对照组治疗的基础上给予HBO治疗,两组观察3个月。结果HBO组与对照组治疗总有效率分别为98.3%和88.3%,HBO组总有效率高于对照组(P<0.05)。治疗后HBO组与对照组平均血流速度分别为(21.49±3.19)和(14.20±4.19)cm/s,高于治疗前的(6.98±2.11)和(6.81±1.99)cm/s(P<0.05),且HBO组治疗后平均血流速度高于对照组(P<0.05)。治疗后HBO组低密度脂蛋白(LDL-C)与高密度脂蛋白(HDL-C)分别为(1.98±0.82)和(1.18±0.24)mmol/L,而对照组分别为(2.68±0.56)和(1.19±0.24)mmol/L,HBO组治疗后LDL-C低于对照组(P<0.05)。结论在脑梗死患者的治疗中的应用HBO能促进患侧大脑中动脉血流速度加快,调节血脂水平,提高治疗总有效率,有良好的效果。

Objective To investigate the effects of hyperbaric oxygen on blood lipid and hemorheology in patients with cerebral infarction. Methods From February 2014 to February 2016, 120 patients with cerebral infarction in our hospital for diagnosis and treatment were selected and were divided into hyperbaric oxygen therapy group (HBO group) and the control group with 60 patients in each group accorded to the principle of random draw envelope. The control group was given routine drug treatment;the HBO group was given hyperbaric oxygen therapy based on the treatment in control group;two groups all were treated for 3 months. Results The total effective rate of treatment group and control group were 98.3% and 88.3%, respectively, and the total effective rate of HBO group was significantly higher than that of control group (P < 0.05). The average blood flow rate after treatment in HBO group and control group were (21.49 ± 3.19) and (14.20 ± 4.19) cm/s, which were significantly higher than (6.98 ± 2.11 cm/s) and (6.81 ± 1.99) cm/s before treatment (P < 0.05), and the average blood flow rate after treatment in HBO group was significantly higher than that in the control group (P < 0.05). After treatment, the LDL-C and HDL-C values in the HBO group were (1.98 ± 0.82) and (1.18 ± 0.24) mmol/L respectively, while the control group were (2.68 ± 0.56) and (1.19 ± 0.24)mmol/L, and the LDL-C value of HBO group was significantly lower than that of control group (P < 0.05). Conclusion The application of hyperbaric oxygen in the treatment of patients with cerebral infarction has a good application effects in promoting the blood flow velocity of the middle cerebral artery and adjusting the blood lipid level so as to improve the total effective rate.