甲壳质酶蛋白40对肾结核的诊断效能及关系研究

Relationship between YKL-40 and renal tuberculosis

目的研究血清甲壳质酶蛋白40(YKL-40)水平对肾结核的诊断效能,分析其与肾结核的关系。方法选取2012年8月—2017年8月河北北方学院附属第一医院收治的46例肾结核患者作为结核组,另选取同期来院体检的46例健康志愿者作为对照组。观察两组血清YKL-40水平,分析YKL-40对肾结核的诊断价值。结果研究组血清YKL-40水平高于对照组(P<0.05);病变组织YKL-40水平高于周围健康组织(P<0.05)。实时荧光定量聚合酶链反应(qRT-PCR)检出肾结核阳性患者30例(32.61%),YKL-40检出阳性患者44例(47.83%),YKL-40检出肾结核阳性率高于PCR(P<0.05)。YKL-40检测ROC曲线下面积为0.930,PCR检测ROC曲线下面积为0.790,YKL-40检测ROC曲线下面积大于PCR(P<0.05)。结论YKL-40检测对肾结核诊断效能较高。

Objective To study the diagnostic efficacy of serum chitosanase 40 (YKL-40) in patients with renal tuberculosis and to analyze its relationship with renal tuberculosis. Methods Forty-six patients with renal tuberculosis who were admitted to our hospital from August 2012 to August 2017 were selected as the tuberculosis group. The other 46 healthy volunteers who were examined in our hospital during the same period were selected as the control group. The levels of serum YKL-40 were observed in two groups and the diagnostic value of YKL- 40 in renal tuberculosis was analyzed. Results The levels of serum YKL-40 in the study group were significantly higher than those in the control group (t = 7.168, P = 0.000). The levels of YKL-40 in the lesions of patients with renal tuberculosis were significantly higher than those in surrounding healthy tissues (t = 4.112, P = 0.000). 30 cases (32.61%) were positive for renal tuberculosis determined by PCR, and 62 cases (67.39%) were negative. However, the positive rate of YKL-40 in detecting renal tuberculosis was higher than that of PCR (P < 0.05). The area under the ROC curve of YKL-40 was 0.930, under the ROC curve of PCR was 0.790, and under the ROC curve of YKL-40 was larger than that of PCR (P < 0.05). Conclusions YKL-40 has higher diagnostic efficacy for renal tuberculosis.