肠道微生物群在肝细胞癌发病机制中的作用

Role of intestinal microflora in the pathogenesis of hepatocellular carcinoma

肝细胞癌(HCC)是最常见的原发性肝癌,是慢性肝病的并发症之一。最近的实验和临床研究表明,肠-肝轴的改变在慢性肝病(包括HCC)的发病中起关键作用。肠道微生物群的改变越来越被认为是促进慢性肝病进展为HCC的关键因素。总结了与HCC相关的肠道微生物菌群变化的最新发现,并讨论了肠道微生物群对HCC发生发展的重要意义。

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and is one of the complications of chronic liver diseases. Recent experimental and clinical studies have shown that the gut-liver axis plays a key role in the pathogenesis of chronic liver diseases including HCC. Change in intestinal microflora is considered the key factor for the progression of chronic liver diseases to HCC. This article summarizes the latest research advances in changes in intestinal microflora associated with HCC and discusses the importance of intestinal microflora in the development and progression of HCC.