摘要
Gilbert综合征是最常见的遗传性高胆红素血症,发病率较高。简述了Gilbert综合征的流行病学特征、常见的尿苷二磷酸葡萄糖醛酸转移酶(UGT)1A1基因突变位点以及Gilbert综合征对肝脏本身及肝外疾病的影响进展,并认为这对Gilbert综合征的诊疗及某些肝脏及肝外疾病的防治具有重要意义。
Gilbert syndrome is the most common type of hereditary hyperbilirubinemia with a high incidence rate. This article briefly describes the research advances in epidemiological characteristics of Gilbert syndrome, common UGT1A1 gene mutation sites, and the influence of Gilbert syndrome on intrahepatic and extrahepatic diseases. It is pointed out that an understanding of these aspects plays an important role in the diagnosis and treatment of Gilbert syndrome and the prevention and treatment of intrahepatic and extrahepatic diseases.
作者
梁晨
白丽
郑素军
LIANG Chen;BAI Li;ZHENG Sujun(Intractable Hepatic Diseases and Artificial Liver Treatment & Training Center,Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research,Beijing YouAn Hospital,Capital Medical University,Beijing 100069,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2019年第7期1632-1635,共4页
Journal of Clinical Hepatology
基金
北京市医院管理局消化内科学科协同发展中心项目(XXZ0503),北京市医院管理局“登峰”人才培养计划基金资助项目(DFL20151601)
北京市医院管理局临床医学发展专项经费资助(ZYLX201806)
科技创新服务能力建设-高精尖学科建设项目(市级)(11920703)
十三五国家科技重大专项(2012ZX10002004-006,2017ZX10203201-005,2017ZX10201201,2017ZX10202203-006-001,2017ZX10302201-004-002)
国家重点研发计划资助(2017YFA0103000)
