摘要
目的研究分析班布特罗联合莫西沙星治疗慢性阻塞性肺疾病急性加重(AECOPD)的疗效及对血气指标动脉血氧分压和动脉血二氧化碳分压与血清C反应蛋白(CRP)、肿瘤坏死因子(TNF-α)、白细胞介素-8(IL-8)、内皮素-1(ET-1)的影响.方法选取2014年4月至2018年4月在我院确诊为AECOPD的病人共118例,随机分为对照组(n=59)和观察组(n=59).在常规治疗基础上,对照组给予莫西沙星治疗;观察组给予班布特罗联合莫西沙星治疗,比较2组临床疗效、血气指标和血清CRP、TNF-α、IL-8、ET-1水平的变化.结果观察组治疗总有效率为91.53%,明显高于对照组(74.58%),差异有统计学意义(P<0.05).治疗后,2组病人血气指标均明显改善,且观察组改善情况更优于对照组,差异有统计学意义(P<0.05).观察组血清CRP、TNF-α、IL-8、ET-1水平较治疗前明显下降,2组比较,差异亦有统计学意义(P<0.05).结论班布特罗联合莫西沙星对于AECOPD病人的治疗效果显著,可明显改善肺功能和炎症因子水平.
Objective To investigate the efficacy of bambuterol combined with moxifloxacin in the elderly patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD),and to investigate the effect on blood gas analysis indexes including PaO2 and PaCO2 and the serum levels of C reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-8(IL-8),and endothelin-1(ET-1).Methods A total of 118 patients with AECOPD in our hospital from April 2014 to April 2018 were selected and divided into control group and observation group randomly,with 59 cases in each group.On the basis of routine treatment,the control group was treated with moxifloxacin,while the observation group was treated with bambuterol combined with moxifloxacin.The efficacy and the changes of blood gas analysis indexes and serum levels of CRP,TNF-α,IL-8,ET-1 in two groups were observed and compared after treatment.Results The total effective rate was 91.53% in treatment group and 74.58% in control group,with significant difference(P<0.05).The blood gas analysis indexes were all improved after treatment in two groups,especially in observation group(P<0.05).After treatment,the serum levels of CRP,TNF-α,IL-8 and ET-1 in observation group were more significantly decreased than those in control group(P<0.05).Conclusions Bambuterol combined with moxifloxacin is effective inthe treatment for elderly patients with AECOPD,which can obviously improve the lung function and the level of inflammatory factor.
作者
郑燕秋
吕俊
古晓娟
胡容
ZHEN Yan-qiu;LV Jun;GU Xiao-juan;HU Rong(Department of Respiratory Medicine,the Second Hospital of Yibin,Yibin 644000,China;Department of Clinical Laboratory,the Second Hospital of Yibin,Yibin 644000,China)
出处
《实用老年医学》
CAS
2019年第7期650-652,共3页
Practical Geriatrics
关键词
班布特罗
莫西沙星
慢性阻塞性肺疾病
急性加重期
炎症因子
bambuterol
moxifloxacin
chronic obstructive pulmonary disease
acute exacerbation
inflammatory factor