运动与2型糖尿病关联性的Meta分析

Association between Physical Activity and Type 2 Diabetes: A Meta-analysis

目的:系统评价体育运动对2型糖尿病发病风险的影响,探讨运动和2型糖尿病的关联性。方法:计算机检索Pub Med、The Cochrane Library、中国期刊全文数据库、万方科技期刊全文数据库、维普中文科技期刊全文数据库,筛选查找运动与2型糖尿病患病风险的观察性研究,对符合纳入标准的文献数据,采用Stata14.0软件进行Meta分析。结果:共纳入18项前瞻性研究,合并结果显示高运动量人群患2型糖尿病的合并效应值RR=0.68(95%CI0.63~0.73),异质性较小,主要来自只针对女性或只针对男性的研究,合并效应值的敏感性较小,纳入文献不存在发表偏倚。纳入的23项回顾性研究,合并效应值OR=0.58(95%CI0.51~0.67),异质性较大且主要来自国内研究,存在一定的发表偏倚。结论:运动可能是2型糖尿病的保护性因素。合理的体育锻炼有助于2型糖尿病的预防和控制。

Objective: To evaluate the influence of physical activity on type 2 diabetes,and to discuss the relationship between physical activity and type 2 diabetes. Methods: Observational studies of relationship between physical activity and type 2 diabetes were searched in PubMed,The Cochrane Library,CNKI,WanFang Data and VIP. All studies which matched both the inclusive criteria and exclusive criteria were analyzed by Stata 14.0 software. Results: 18 prospective studies were involved in our study. The summary RR for high versus low physical activity was 0.68,95%CI=0.63~ 0.73 . There was some evidence of heterogeneity from research of single sex. There was little evidence of sensitivity or publication bias among these studies. 23 retrospective studies were also involved in our study. The summary OR for high versus low physical activity was 0.58,95% CI 0.51~0.67. There was some evidence of heterogeneity from research in China. There was some indication of publication bias among retrospective studies. Conclusions: Physical activity were associated with a statistically significant reduction in the risk of type 2 diabetes. Moderate physical activity may contribute to protection and control of type 2 diabetes.