γ-谷氨酰转移酶水平与冠状动脉造影正常的胸痛患者冠状动脉微循环阻力指数的相关性研究

Correlation between Gamma-glutamyl Transpeptidase and Index of Microcirculatory Resistance in Chest Pain Patients Presenting Normal Coronary Angiography

背景 冠状动脉微循坏阻力指数(IMR)是反映冠状动脉微循环功能的有效指标,而γ-谷氨酰转移酶(GGT)是独立于传统心血管危险因素的预测因子,但目前国内关于GGT与IMR的关系研究报道较少见。目的 探讨GGT水平与冠状动脉造影正常的胸痛患者IMR的相关性。方法 选取2013年3月—2017年12月江苏省苏北人民医院心内科收治的冠状动脉造影正常的胸痛患者44例,根据IMR分为A组(IMR<25,n=29)和B组(IMR≥25,n=15)。比较两组患者一般资料〔包括性别、年龄、高血压病史、糖尿病病史、吸烟史等〕、实验室检查指标〔包括GGT、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、血肌酐(Scr)、尿素氮(BUN)、血尿酸(SUA)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)〕;GGT与冠状动脉造影正常的胸痛患者IMR的相关性分析采用Pearson相关分析及多元线性回归分析。结果 (1)两组患者性别、年龄、高血压病史、糖尿病病史、吸烟史、GGT、ALT、AST、Scr、BUN、SUA、TC、HDL-C、LDL-C、TG比较,差异无统计学意义(P>0.05)。(2)Pearson相关分析结果显示,GGT与冠状动脉造影正常的胸痛患者IMR呈正相关(r=0.401,P<0.01);多元线性回归分析结果显示,GGT与冠状动脉造影正常的胸痛患者IMR呈正相关(β=0.236,P<0.05)。结论 GGT水平与冠状动脉造影正常的胸痛患者IMR呈正相关,可在一定程度上反映冠状动脉微循环功能。

Background Index of microcirculatory resistance(IMR)is an effective indicator for reflecting coronary microcirculation function,while gamma-glutamyl transpeptidase(GGT)is an independent predictive factor compared with traditional cardiovascular risk factors,but reports about relationship between GGT and IMR is relatively rare at home. Objective To investigate correlation between GGT and IMR in chest pain patients presenting normal coronary angiography. Methods From March 2013 to December 2017,a total of 44 chest pain patients presenting normal coronary angiography were selected in the Department of Cardiology,Northern Jiangsu People's Hospital,and they were divided into A group(with IMR less than 25,n=29)and B group(with IMR equal or over 25,n=15)according to the IMR. General information(including gender, age,history of hypertension,diabetes and smoking)and laboratory examination results(including GGT,ALT,AST, Scr,BUN,SUA,TC,HDL-C,LDL-C and TG)were compared between the two groups;Pearson correlation analysis and multivariate linear regression analysis were used to analyze the correlation between GGT and IMR in chest pain patients presenting normal coronary angiography. Results (1)There was no statistically significant difference in gender,age,history of hypertension,diabetes or smoking,GGT,ALT,AST,Scr,BUN,SUA,TC,HDL-C,LDL-C or TG between the two groups(P>0.05).(2)Pearson correlation analysis results showed that,GGT was positively correlated with IMR in chest pain patients presenting normal coronary angiography(r=0.401,P<0.01);linear regression analysis results showed that, GGT was positively correlated with IMR in chest pain patients presenting normal coronary angiography(β=0.236,P<0.05). Conclusion GGT is positively correlated with IMR in chest pain patients presenting normal coronary angiography,may reflect the coronary microcirculation function to some extent.