多模态磁共振与CD151、SNAT1联合检测在颅脑胶质瘤诊断中的意义

Clinical Significance of Combined Detection of Multimodality Magnetic Resonance Imaging and CD151 and SNAT1 in Diagnosis of Gliomas

目的分析多模态磁共振与CD151、人钠耦合中性氨基酸转运蛋白1(SNAT1)联合检测在颅脑胶质瘤诊断中的意义。方法回顾性分析2016年11月-2017年11月本院收治的48例高级别颅脑胶质瘤患者,将其作为高级别胶质瘤组;另选取64例低级别颅脑胶质瘤患者,将其作为低级别胶质瘤组;同时选取我院进行颅脑检查的60例无颅脑胶质瘤患者,将其作为对照组。对以上所有受试者进行颅脑多模态磁共振检查,并测定各组患者CD151、SNAT1阳性率。统计并分析各诊断方法在高级别颅脑胶质瘤中的诊断效果。结果高级别胶质瘤组CD151、SNAT1阳性率明显高于对照组及低级别胶质瘤组(P<0.05)CD151+磁共振、SNAT1+磁共振及CD151+SNAT1+磁共振诊断高级别胶质瘤的ROC曲线如图1,平行联合检测ROC曲线下面积分别为0.716、0.785和0.918,系列联合检测ROC曲线下面积为0.784、0.748和0.903,CD151+SNAT1+磁共振诊断的ROC曲线下面积显著高于CD151+磁共振、SNAT1+磁共振(P<0.05),具有统计学意义。结论多模态磁共振与CD151、SNAT1联合检测能有效提高颅脑胶质瘤诊断特异性及敏感性,值得临床推广。

Objective To explore and analyze the significance of combined detection of multimodality magnetic resonance imaging and CD151 and SNAT1 in the diagnosis of gliomas. Methods A retrospective analysis of 48 patients with high grade glioma in our hospital from November 2016 to November 2017 was used as a high grade glioma group,and 64 patients with low grade brain glioma were selected as the low grade glioma group,and 60 cases of brain glioma without brain glioma were selected in our hospital. It was used as a control group. All patients were examined by multi modality magnetic resonance imaging and the positive rates of CD151 and SNAT1 were measured. The diagnostic effects of different diagnostic methods in high-grade gliomas were statistically analyzed.Results The positive rate of CD151 and SNAT1 in the high grade glioma group was significantly higher than that of the control group and the low grade glioma group(p<0.05).CD151+ magnetic resonance, SNAT1+ magnetic resonance, and CD151+SNAT1+ MRI were used to diagnose the ROC curve of high grade gliomas, such as Figure 1. The area under the parallel joint detection of ROC curves was 0.716, 0.785 and 0.918 respectively.The area under the series joint detection ROC curves was the area of the joint detection.0.784, 0.748, and 0.903, the area under the ROC curve diagnosed by CD151+SNAT1+MRI was significantly higher than that of CD151+ MRI and SNAT1+ MRI(P<0.05),which had statistical significance. Conclusion Combined detection of multimodality magnetic resonance and CD151 and SNAT1 can effectively improve the specificity and sensitivity of diagnosis of gliomas, and is worthy of clinical promotion.