摘要
Aristolochic acids (AA) are the etiologic agents of aristolochic acid nephropathy (AAN) and contribute to the global prevalence of chronic kidney disease and urothelial cancer (Grollman et al.,2007).DNA adducts formed by AA generate a unique A>T transversions mutation spectrum at adenine exclusively on the non-transcribed strand (strand bias).
基金
supported by grants from the National Science and Technology Major Project(2018ZX09101002-002)
