组蛋白脱乙酰基酶及其抑制剂对肿瘤的作用

Effect of histone deacetylase and its inhibitor on tumor

肿瘤的发生和进展是遗传和表观遗传共同作用的结果。组蛋白脱乙酰化修饰作为重要的表观遗传修饰的一种,对肿瘤的发生与发展有不可忽视的作用。组蛋白脱乙酰基酶在正常组织及细胞中的异常表达,会促进肿瘤的发展,并与肿瘤细胞的增殖和凋亡、血管生成、转移及耐药等方面相关,成为肿瘤治疗的新靶点。组蛋白脱乙酰基酶抑制剂作为抗肿瘤药物显示出良好的应用前景。

The occurrence and progress of tumor is the result of the interaction of heredity and epigenetics. Histone deacetylation modification, as an important epigenetic modification, plays an important role in tumorigenesis and development. The abnormal expression of histone deacetylase in normal tissues and cells promotes the development of tumor and is related to the proliferation and apoptosis, angiogenesis, metastasis and drug resistance of tumor cells, and becomes a new target of tumor therapy. Histone deacetylase inhibitors as anti-tumor drugs have a good prospect of application.