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度洛西汀与西酞普兰治疗冠心病 PCI术后合并焦虑抑郁患者临床对照研究 被引量:4

A clinical controlled study of duloxetine and citalopram in the treatment of patients with coronary heart disease complicated with anxiety and depression after PCI
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摘要 目的探讨度洛西汀与西酞普兰治疗冠心病经皮冠状动脉介入治疗术后合并焦虑抑郁患者的临床疗效.方法将80例冠心病经皮冠状动脉介入治疗术后合并焦虑抑郁的患者按照随机数字表法分为两组,每组40例.治疗组给予度洛西汀治疗,对照组给予西酞普兰治疗.于治疗前及治疗2周、4周、8周末采用广泛性焦虑障碍量表及病人健康问卷抑郁量表评定两组患者的焦虑、抑郁状况,比较两组患者临床疗效、不良心血管事件发生率及不良反应发生率.结果治疗2周末起两组广泛性焦虑障碍量表及病人健康问卷抑郁量表评分均较治疗前显著持续降低(P<0.01),治疗2周末及4周末治疗组较对照组评分下降更显著(P<0.05或0.01),治疗8周末两组评分比较差异无统计学意义(P>0.05).两组临床疗效、不良心血管事件发生率及不良反应发生率比较差异均无统计学意义(P>0.05).结论度洛西汀与西酞普兰均可有效改善冠心病经皮冠状动脉介入治疗术后患者的焦虑抑郁状况,且两种药物安全性均较高,但度洛西汀起效更快,短时间内临床缓解率较高,值得临床推广使用. Objective To investigate the clinical efficacy of duloxetine and citalopram in the treatment of patients with coronary heart disease complicated with anxiety and depression after PCI.Methods 80 patients with coronary heart disease w ho underw ent percutaneous coronary intervention with anxiety and depression were divided into two groups according to the random number table,40 cases in each group.The treatment group was treated with duloxetine and the control group was treated with citalopram.GAD-7 and PH Q-9 were used to assess anxiety and depression in the two groups before treatment and at 2,4,and 8 weeks of treatment.The clinical efficacy,incidence of adverse cardiovascular events and incidence of adverse reactions were compared between the two groups.Results After 2 weeks of treatment,the scores of GAD-7 and PH Q-9 in the two groups were significantly lower than those before treatment ( P<0.01). At the 2nd and 4th w eekends of treatment,the scores of the treatment group were significantly lower than those of the control group ( P<0.05 or 0.01).There was no significant difference between the two groups at the end of the 8th week ( P>0.05 ).There were no significant differences in clinical outcomes,incidence of adverse cardiovascular events,and incidence of adverse reactions between the two groups ( P>0.05).Conclusion Bo th duloxetine and citalopram can effectively improve the anxiety and depression of patients with coronary heart disease af ter percutaneous coronary intervention,and the safety of both drugs is higher.Duloxetine has a faster onset of action and a higher rate of clinical remission in a short period of time,which is worthy of clinical promotion.
作者 石瑞 杨喜山 纪翠锋 Shi Rui;Yang Xishang;Ji Cuifeng(Clinical Medical College of Henan University of Science and Technology,Luoyaang 471003,Henan,China)
出处 《临床心身疾病杂志》 CAS 2019年第4期36-39,共4页 Journal of Clinical Psychosomatic Diseases
关键词 冠心病 经皮冠状动脉介入治疗 度洛西汀 西酞普兰 焦虑 抑郁 Coronary heart disease percutaneous coronary intervention duloxetine citalopram anxiety depression
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