依托考昔联合硫酸氨基葡萄糖治疗膝关节骨性关节炎疗效观察

Therapeutic effect of etoricoxib combined with glucosamine sulfate on knee osteoarthritis

目的探讨依托考昔联合硫酸氨基葡萄糖治疗膝关节骨性关节炎的临床疗效.方法将103例膝关节骨性关节炎患者按随机数字表法观察组52例与对照组51例.两组均给予依托考昔治疗,观察组联合硫酸氨基葡萄糖治疗,观察25d-28d.治疗前后采用西大略湖麦克马斯特骨性关节炎量表定两组的临床效果,并统计不良反应发生状况.结果观察组总有效率为96.15%,对照组为82.35%,观察组总有效率显著高于对照组(P<0.05).治疗后两组西大略湖麦克马斯特骨性关节炎量表评分均显著低于治疗前(P<0.01),观察组较对照组下降更显著(P<0.01).两组患者不良反应发生率比较差异无统计学意义(P>0.05).结论依托考昔联合盐酸氨基葡萄糖治疗膝关节骨性关节炎疗效显著,且不增加患者的不良反应,值得临床推广应用.

Objective To study the clinical efficacy of etoricoxib combined with glucosamine sulfate on knee osteoarthritis.Methods 103 patients with knee osteoarthritis were randomly divided into the observation group (52 cases) and control group (51 cases).Both groups were treated with etoricoxib.The observation group was treated with glucosamine sulfate for 25 d to 28 d.Before and after treatment,the clinical effect and adverse reactions of the two groups were determined by the Western Great Lakes McM aster Osteoarthritis Scale.Results The total effective rate was 96.15% in the observation group and 82.35% in the control group.The total effective rate of the observation group was significantly higher than that of the control group (P<0.05).After treatment,the scores of the Western Great Lakes McM aster Osteoarthritis Scale were significantly lower than before treatment ( P<0.01).The observation group decreased more significantly than the control group ( P<0.01).There was no significant difference in the incidence of adverse reactions between the two groups ( P>0.05 ).Conclusion Etoricoxib combined with glucosamine sulfate is effective in the treatment of knee osteoarthritis,and does not increase the adverse reactions of patients,and is worthy of clinical application.