毛细血管渗漏综合征发病机制的研究进展

Progress on pathogenesis of capillary leak syndrome

毛细血管渗漏综合征是血管内皮高渗透性导致全身水肿、休克、低蛋白血症及血液浓缩的疾病,严重时可致多脏器功能衰竭,急性期病死率高。了解毛细血管渗漏综合征的发病机制对于早期诊断及治疗意义重大。血管内皮高通透性是毛细血管渗漏综合征发病机制的核心,本文从血清学机制、血管内皮结构改变及遗传因素方面对本病发病机制的研究进展进行综述。

Capillary leak syndrome is a disease characterized by high permeability of vascular endothelium leading to anasarca, hypotension, hypoalbuminemia and hemoconcentration, It can cause multiple organ failure and high mortality in acute stage.Vascular endothelial hyperpermeability is the core of pathogenesis of capillary leak syndrome.This article reviewed the latest research progress on the pathogenesis of capillary leak syndrome from the aspects of serological mechanism, histological changes and genetic factors.