溶致液晶在中药新型给药系统中的研究现状、存在问题及其对策

Research Status,Problems and Countermeasures of Lyotropic Liquid Crystal in New Drug Delivery Systems of Traditional Chinese Medicine

溶致液晶(LLC)是由两亲性分子溶于极性溶剂中后相互缔结形成的具有各种几何形状或三维结构的有序体系,通常具有优异的载药适用性、较高的载药量、较好的生物黏附性及透皮促渗性等特点。笔者通过综合分析课题组前期对LLC给药系统的研究经验、成果以及相关研究报道,系统论述了LLC在中药新型给药系统领域,尤其是中药经皮及黏膜给药系统以及中药口服微粒给药系统方面的研究现状、研究价值以及开发潜力。由于目前中药领域LLC研究起步较晚,存在的诸多基础研究问题有待于进一步完善,该文对这些问题进行了归纳总结,并提出了相应研究对策:①基于对单一化学成分LLC的研究方法,结合中药自身特点,进一步加强对中药LLC给药系统的基础研究;②加强中药化学成分释药机制的研究,并进行同步缓释中药LLC给药系统的基础研究;③开发适用于中药的新型LLC材料;④完善中药LLC质量评价体系;⑤探索适用于产业化的LLC制备工艺。

Lyotropic liquid crystal is an ordered system with various geometric shapes or threedimensional structures formed by the interaction of amphiphilic molecules dissolved in polar solvents,and has the characteristics of excellent drug applicability,high drug loading,good bioadhesive property and high transdermal permeability.Through a comprehensive analysis of the research results in this research group and the related research reports of LLC drug delivery system,the authors systematically discussed the research value,development potential and research status of LLC in the field of new drug delivery system of traditional Chinese medicine(TCM),especially in the percutaneous and mucosal drug delivery system and the oral microparticle drug delivery system of TCM.At the same time,due to the current research field of TCM-LLC drug delivery system starts late,many of the basic research problems to be further perfect,this paper had carried on the induction summary to these problems,and put forward the research countermeasures:①the basic research of TCM-LLC drug delivery system should be strengthened by referencing the research experience and methods of LLC drug delivery system of single chemical component combined with TCM characteristics,②the research on the release mechanism of the chemical components in TCM should be strengthened, and the basic research on the LLC drug delivery system of synchronized sustained release TCM should be carried out,③ development of new LLC materials applicable to TCM,④the quality evaluation system of TCM-LLC should be improved,⑤to explore the LLC preparation process suitable for industrialization.