芪参益气滴丸联合尿激酶对心肌梗死患者血脂水平和左心室功能的影响

Effect of Qishen Yiqi Dripping Pills combined with urokinase on blood lipid level and left ventricular function in patients with myocardial infarction

目的研究芪参益气滴丸联合尿激酶对心肌梗死患者血脂水平和左心室功能的影响。方法选择2015年1月-2017年12月新疆生产建设兵团第六师医院收治的120例心肌梗死患者,随机分为两组。对照组单纯静脉滴注尿激酶,观察组联合餐后服用芪参益气滴丸。两组均治疗8周。比较两组的血脂水平、左心室功能和预后情况。结果观察组的有效率明显高于对照组,差异有统计学意义(P<0.05)。两组治疗后的三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和总胆固醇(TC)水平均明显降低,高密度脂蛋白胆固醇(HDL-C)水平明显升高,同组治疗前后比较差异均有统计学意义(P<0.05),且观察组血脂改善更为明显,组间差异有统计学意义(P<0.05)。两组的左心室射血分数(LVEF)、左心室舒张末期内径(LVDs)、左心室后壁厚度(LVPWT)均较治疗前明显改善,同组治疗前后比较差异有统计学意义(P<0.05),且观察组更为明显,组间差异有统计学意义(P<0.05)。观察组的再梗死、心源性休克、心律失常和心绞痛发生率均明显低于对照组,差异有统计学意义(P<0.05)。结论芪参益气滴丸联合尿激酶有助于提高心肌梗死患者的治疗效果,改善血脂水平、左心室功能和预后情况,值得应用推广。

Objective To investigate the effect of Qishen Yiqi Dripping Pills combined with urokinase on blood lipid level and left ventricular function in patients with myocardial infarction.Methods Selected 120 cases of patients with myocardial infarction who were treated in Xinjiang Production and Construction Corps Agricultural Construction Sixth Division from January 2015 to December 2017,divided into two groups randomly.The control group was intravenously injected with urokinase,and the observation group received Qishen Yiqi Dripping Pills after meals.Results After treatment,the effective rate of the observation group was significantly higher than control group (P<0.05).The levels of TG,LDL-C and TC in the two groups were significantly decreased (P<0.05),and the HDL-C level increased significantly (P<0.05),and the observation group was more significant (P<0.05).The LVEF,LVDs and LVPWT were significantly improved (P<0.05),and the observation group was more obvious (P<0.05).The incidence of reinfarction,cardiogenic shock,arrhythmia and angina pectoris in the observation group were significantly lower than those in the control group (P<0.05).Conclusion Qishen Yiqi Dripping Pills combined with urokinase can improve the therapeutic effect,improve blood lipid level,left ventricular function and prognosis in patients with myocardial infarction.