5-羟色胺再摄取抑制剂在缺血性脑卒中中的应用及机制研究进展

Advance in Clinial and Mechanism Reseaches about Serotonin Selective Reuptake Inhibitors for Ischemic Stroke(review)

以往5-羟色胺再摄取抑制剂(SSRIs)被广泛应用于改善脑卒中后抑郁,近年来SSRIs被认为是改善缺血性脑卒中后运动功能障碍的有效药物.目前关于SSRIs改善脑缺血后运动功能的机制研究内容较广泛,尚无统一结论;SSRIs能否确切改善脑缺血后运动功能存在矛盾的观点,且SSRIs应用于脑卒中治疗存在潜在风险.应有效评估SSRIs应用的收益与风险.

Serotonin selective reuptake inhibitors (SSRIs) have been widely used for post-stroke depression. Recently, SSRIs are considered as an effective drug to improve motor function after stroke. Mechanism of SSRIs improving motor function after ischemic stroke involves extensive factors, and there is no definitive conclusion yet. While, the effects of SSRIs on motor function after stroke remains debatable. Besides, there are potential risks of SSRIs in the treatment of stroke. It is necessary to evaluate the benefits and risks of SSRIs for patients with ischemic stroke.