扶正抑瘤汤联合化疗对前列腺癌患者血清TGF-β、IL-1A和PSA水平的影响及其疗效分析

Effects of FuzhengYiliu Decoction Combined with Chemotherapy on Serum TGF-β, IL-1A and PSA Levels and Curative Efficiency of Prostate Cancer Patients and Their Correlation Analysis

目的 探讨扶正抑瘤汤联合化疗对前列腺癌患者血清TGF-β、IL-1A和PSA水平和疗效的影响及其相互关系。方法 选取前列腺癌患者72例随机分为观察组和对照组,每组36例。对照组采用常规吉西他滨+顺铂化疗,观察组在对照组的基础上联合扶正抑瘤汤治疗。对两组患者进行疗效评价并比较治疗有效率、治疗前、治疗1个疗程和2个疗程后血清TGF-β、IL-1A和PSA水平及细胞免疫水平,并分析观察组以上指标与疗效间的关系。结果 观察组治疗有效率86.11%(31/36)显著高于对照组63.89%(23/36)(P<0.05)。观察组治疗1个疗程和2个疗程的CD3^+、CD4^+及CD4^+/CD8^+水平均较治疗前升高,且显著高于对照组(P<0.05);血清TGF-β、IL-1A、PSA及CD8+水平较治疗前降低,且显著低于对照组(P<0.05)。对照组治疗2个疗程的CD3^+、CD4^+及CD4^+/CD8^+水平均较治疗前升高,血清TGF-β、IL-1A、PSA及CD8+水平则较治疗前降低(P<0.05)。Pearson线性分析显示,观察组血清TGF-β、IL-1A、PSA水平与其CD3^+、CD4^+及CD4^+/CD8^+水平均呈负相关(P<0.05),与CD8^+水平呈正相关(P<0.05)。观察组中,与治疗有效患者相比,治疗无效患者治疗前后CD3^+、CD4^+、CD4^+/CD8^+水平均降低,血清TGF-β、IL-1A、PSA及CD8+水平则升高,差异均有统计学意义(P<0.05)。Spearman相关分析显示,血清患者TGF-β、IL-1A和PSA水平与疗效呈负相关(P<0.05)。结论 扶正抑瘤汤联合化疗有助于改善前列腺癌患者的疗效,降低血清TGF-β、IL-1A、PSA水平,且血清TGF-β、IL-1A、PSA水平与免疫功能和疗效均密切相关。

Objective To investigate the influence of modified Fuzheng Yiliu decoction combined with chemotherapy on the curative efficiency and serum TGF-β, IL-1A and PSA levels of prostate cancer patients and their correlation. Methods Seventy-two patients with prostate cancer were randomly divided into observation group (n=36) and control group (n=36). Patients in control group got gemcitabine plus cisplatin chemotherapy. The observation group was treated with Fuzheng Yiliu Decoction combined with gemcitabine and cisplatin. The effective rates of the two groups were evaluated and compared. The serum TGF-β, IL-1A and PSA levels and cellular immunity were detected before treatment and after 1 course and 2 courses treatment. The relationships of the above indicators in the observation group with the curative effect were analyzed. Results The effective rate of observation group was 86.11%(31/36), which was higher than the 63.89%(23/36) of the control group (P<0.05). After one course of treatment and two courses of treatment, the CD3^+ and CD4^+ levels and CD4^+/CD8^+ of the observation group increased as compared with before treatment, and were higher than those of the control group (P<0.05). Yet the serum TGF-β, IL-1A and PSA levels and CD8^+ of the observation group decreased, and were lower than those of the control group (P<0.05).In the control group, the CD3^+, CD4^+ levels and CD4+/CD8+ increased, while serum TGF-β, IL-1A and PSA levels and CD8+ decreased after two courses of treatment, as compared with before treatment (P<0.05). Pearson linear correlation analysis showed that the serum levels of TGF-β, IL-1A and PSA in observation group were negatively correlated with CD3^+ and CD4^+ levels and CD4^+/CD8^+, but positively correlated with CD8+ level (P<0.05). In addition, in the observation group, the levels of CD3^+ and CD4^+ and CD4^+/CD8^+ before and after treatment of the patients with ineffective treatment were lower than those of patients who got curative effects, however, their serum TGF-β, IL-1A and PSA levels and CD8+ were higher those of the patients who got curative effects (P<0.05). Spearman correlation analysis showed that serum TGF-β, IL-1A and PSA levels in observation group were negatively correlated with the curative effect (P<0.05). Conclusion Combination of chemotherapy with Fuzheng Yiliu decoction for prostate cancer can improve the curative effect and reduce the serum TGF-β, IL-1A and PSA levels. The serum TGF-β, IL-1A and PSA levels are closely related to the immune function and curative effect.