左五合方对卵巢低反应者IVF/ICSI-ET助孕结局的影响

Effect of Zuowu Decoction on the Outcome of Poor Ovarian Response Patients with IVF/ICSI-ET

目的评价左五合方对卵巢低反应(POR)者体外受精/卵胞质内单精子注射-胚胎移植(IVF/ICSI-ET)卵巢反应性、妊娠相关指标的影响.方法将100例肾精不足合脾气虚型POR患者随机分为治疗组和对照组各50例,2组均常规行IVF/ICSI-ET,其中治疗组以左五合方治疗3月再行IVF/ICSI-ET.比较2组患者促性腺激素(Gn)用量及用药天数、人绒毛膜促性腺激素(HCG)注射日雌二醇(E2)及孕酮(P)水平、获卵数、优胚率、生化妊娠率、临床妊娠率、持续妊娠率.结果 2组Gn用量及用药天数、HCG日E2和P水平、优胚率、生化妊娠率差异均无统计学意义(P>0.05);治疗组获卵数、临床妊娠率、持续妊娠率均高于对照组(P<0.05).结论左五合方能提高POR者IVF/ICSI-ET的获卵数、临床妊娠率和持续妊娠率.

OBJECTIVE To evaluate the impact of Zuowu decoction on ovarian response and pregnancy related indicators of poor ovarian response (POR) patients with in vitro fertilization/ intracytoplasmic sperm injection embryo transfer (IVF/ICSI-ET). METHODS 100 patients with POR due to deficiency of kidney essence and spleen qi were randomly divided into the treatment group and the control group with 50 cases in each. Both groups received routine IVF/ICSI-ET while the treatment group was pre administrated with Zuowu Decoction for 3 months, and then given IVF/ICSI-ET. The dosage and administration duration of gonadotropin (Gn), the levels of estradiol (E 2) and progesterone (P) on human chorionic gonadotropin(HCG) trigger day, number of retrieved oocytes, high quality embryo rates, biochemical pregnancy rate, clinical pregnancy rate and ongoing pregnancy rate were compared between the two groups. RESULTS The differences of the following indicators were no statistically significant: the dosage and administration duration of Gn, the level of E 2 and P on HCG trigger day, high quality embryo rates and biochemical pregnancy rate ( P > 0.05 ). The number of retrieved oocytes, clinical pregnancy rate and ongoing pregnancy rate in the treatment group were all higher than those in the control group (P<0.05 ). CONCLUSION Zuowu Decoction can increase the number of retrieved oocytes, clinical pregnancy rate and ongoing pregnancy rate in POR patients with IVF/ICSI-ET treatment.