抗MDA5抗体在无肌病皮肌炎诊断中的意义

Significance of Anti-MDA5 Antibody in the Diagnosis of No Myopathy Myositis

目的探讨抗黑色瘤分化相关基因(MDA5)抗体对无肌病皮肌炎(ADM)的诊断意义。方查阅270例资料完整的风湿病患者的住院病历,其中无肌病皮肌炎(ADM)患者30例(ADM组),非ADM患者240例(非ADM组)。检测患者外周血抗MDA5抗体。计算抗MDA5抗体的敏感度和特异度,并对两组患者检测结果进行对比分析。结果抗MDA5抗体在ADM组患者血清中的阳性率33.33%,非ADM组阳性率0.42%。抗MDA5抗体对ADM的敏感性和特异性分别为33.33%和99.58%。结论抗CCP抗体对ADM具有一定的敏感性和高度的特异性,对ADM的诊断具有重要意义。

Objective To investigate the diagnostic value of anti-melanoma differentiation related gene(MDA5) antibody in the absence of myopathy dermatomyositis(ADM). Methods A total of 270 inpatients with complete data on rheumatic diseases were enrolled, including 30 patients with no myopathy dermatomyositis(ADM)(ADM group) and 240 patients with non-ADM(non-ADM group). The patient’s peripheral blood anti-MDA5 antibody was detected. The sensitivity and specificity of anti-MDA5 antibodies were calculated, and the results of the two groups were compared and analyzed.Results The positive rate of anti-MDA5 antibody in serum of ADM group was 33.33%, and the positive rate of non-ADM group was 0.42%. The sensitivity and specificity of anti-MDA5 antibodies to ADM were 33.33% and 99.58%, respectively. Conclusion Anti-CCP antibody has certain sensitivity and high specificity to ADM, which is of great significance for the diagnosis of ADM.